13-Hidroksilupinin O-tigloiltransferaza
(Preusmjereno sa stranice 13-hidroksilupinin O-tigloiltransferaza)
| 13-Hidroksilupinin O-tigloiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.93 | ||||||||
| CAS broj | 85341-00-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
13-Hidroksilupinin O-tigloiltransferaza (EC 2.3.1.93, tigloil-KoA:13-hidroksilupanin O-tigloiltransferaza, 13-hidroksilupanin aciltransferaza) je enzim sa sistematskim imenom (E)-2-metilkrotonoil-KoA:13-hidroksilupanin O-2-metilkrotonoiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (E)-2-metilkrotonoil-KoA + 13-hidroksilupanin KoA + 13-[(E)-2-metilkrotonoil]oksilupanin
Benzoil-KoA, pentanoil-KoA, 3-metilbutanoil-KoA i butanoil-KoA mogu da deluju kao acil donori. Ovaj enzim učestvuje u sintezi lupaninskih alkaloida.
Reference[uredi | uredi kod]
- ↑ Wink, M. and Hartmann, T. (1982). „Enzymatic synthesis of quinolizidine alkaloid esters: a tigloyl-CoA:13-hydroxylupanine O-tigloyl transferase from Lupinus albus L”. Planta 156: 560-565.
- ↑ Okada, T.. Hirai, M.Y., Suzuki, H., Yamazaki, M. and Saito, K. (2005). „Molecular characterization of a novel quinolizidine alkaloid O-tigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants”. Plant Cell Physiol. 46: 233-244.
- ↑ Suzuki, H., Murakoshi, I. and Saito, K. (1994). „A novel O-tigloyltransferase for alkaloid biosynthesis in plants. Purification, characterization, and distribution in Lupinus plants”. J. Biol. Chem. 269: 15853-15860. PMID 8195240.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.