1-hidroksikarotenoid 3,4-desaturaza
Izgled
1-hidroksikarotenoid 3,4-desaturaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.3.99.27 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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1-hidroksikarotenoid 3,4-desaturaza (EC 1.3.99.27, CrtD, hidroksineurosporenska desaturaza, karotenoidna 3,4-dehidrogenaza, 1-hidroksi-karotenoidna 3,4-dehidrogenaza) je enzim sa sistematskim imenom 1-hidroksi-1,2-dihidrolikopen:akceptor oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-hidroksi-1,2-dihidrolikopen + akceptor 1-hidroksi-3,4-didehidro-1,2-dihidrolikopen + redukovani akceptor
Ovi enzimi iz Rubrivivax gelatinosus i Rhodobacter sphaeroides preferentno deluju na aciklične karotenoide (e.g. 1-hidroksi-1,2-dihidroneurosporen, 1-hidroksi-1,2-dihidrolikopen). Brzina konverzije za 3,4-desaturaciju monocikličnog 1'-hidroksi-1',2'-dihidro-gama-karotena je niža.
- ↑ Teramoto, M., Rahlert, N., Misawa, N. and Sandmann, G. (2004). „1-Hydroxy monocyclic carotenoid 3,4-dehydrogenase from a marine bacterium that produces myxol”. FEBS Lett. 570: 184-188. PMID 15251462.
- ↑ Steiger, S., Astier, C. and Sandmann, G. (2000). „Substrate specificity of the expressed carotenoid 3,4-desaturase from Rubrivivax gelatinosus reveals the detailed reaction sequence to spheroidene and spirilloxanthin”. Biochem. J. 349: 635-640. PMID 10880364.
- ↑ Albrecht, M., Ruther, A. and Sandmann, G. (1997). „Purification and biochemical characterization of a hydroxyneurosporene desaturase involved in the biosynthetic pathway of the carotenoid spheroidene in Rhodobacter sphaeroides”. J. Bacteriol. 179: 7462-7467. PMID 9393712.
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