Manozil-oligosaharid 1,2-alfa-manozidaza
(Preusmjereno sa stranice 1,2-alfa-manozidaza)
| Manozil-oligosaharid 1,2-alfa-manozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.113 | ||||||||
| CAS broj | 9068-25-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Manozil-oligosaharid 1,2-alfa-manozidaza (EC 3.2.1.113, manozidaza 1A, manozidaza 1B, 1,2-alfa-manozidaza, ekso-alfa-1,2-mananaza, manoza-9 alfa-manozidaza, glikoproteinska manozidaza I, manozidaza I, Man9-manozidaza, ManI, 1,2-alfa-manozil-oligosaharid alfa-D-manohidrolaza) je enzim sa sistematskim imenom 2-alfa-manozil-oligosaharid alfa-D-manohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza terminalnih (1->2)-vezanih alfa-D-manoznih ostataka u oligo-manoznom oligosaharidu Man9(GlcNAc)2
Ovaj enzim učestvuje u sintezi glikoproteina.
Reference[uredi | uredi kod]
- ↑ Tabas, I. and Kornfeld, S. (1979). „Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides”. J. Biol. Chem. 254: 11655-11663. PMID 500665.
- ↑ Tulsiani, D.R.P., Hubbard, S.C., Robbins, P.W. and Touster, O. (1982). „α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates”. J. Biol. Chem. 257: 3660-3668. PMID 7061502.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.