(Metil-Co(III) metilamin-specifični korinoid protein):koenzim M metiltransferaza

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(Metil-Co(III) metilamin-specifični korinoid protein):koenzim M metiltransferaza
Identifikatori
EC broj 2.1.1.247
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

(Metil-Co(III) metilamin-specifični korinoid protein):koenzim M metiltransferaza (EC 2.1.1.247, metiltransferaza 2, MT2, MT2-A, mtbA (gen)) je enzim sa sistematskim imenom korinoidni protein specifičan za metilisani monometilamin:koenzim M metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

[metil-Co(III) metilamin-specifični korinoidni protein] + koenzim M \rightleftharpoons metil-KoM + [Co(I) metilamin-specifični korinoidni protein]

Ovaj enzim sadrži cink. Enzim koji učestvuje u metanogenezi sa mono-, di-, i trimetilamina, katalizuje transfer metil grupa vezanih za kobaltni kofaktor nekoliko korinoidnih proteina.

Reference[uredi - уреди]

  1. Burke, S.A. and Krzycki, J.A. (1995). "Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine". J. Bacteriol. 177: 4410-4416. PMID 7635826. 
  2. LeClerc, G.M. and Grahame, D.A. (1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression". J. Biol. Chem. 271: 18725-18731. PMID 8702528. 
  3. Ferguson, D.J., Jr. and Krzycki, J.A. (1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri". J. Bacteriol. 179: 846-852. PMID 9006042. 
  4. Burke, S.A., Lo, S.L. and Krzycki, J.A. (1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". J. Bacteriol. 180: 3432-3440. PMID 9642198. 
  5. Ferguson, D.J., Jr., Gorlatova, N., Grahame, D.A. and Krzycki, J.A. (2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 275: 29053-29060. PMID 10852929. 

Literatura[uredi - уреди]

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