(KDO)3-lipid IVA (2-4) 3-dezoksi-D-manno-oktulozonska kiselina transferaza
| (KDO)3-lipid IVA (2-4) 3-dezoksi-D-manno-oktulozonska kiselina transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.15 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(KDO)3-lipid IVA (2-4) 3-dezoksi-D-manno-oktulozonska kiselina transferaza (EC 2.4.99.15, KDO transferaza, waaA (gen), kdtA (gen), 3-dezoksi-D-mano-oct-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-okt-2-ulozonat:(KDO)3-lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza ((2->4) formira glikozidnu vezu).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alfa-Kdo-(2->8)-alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP-alfa-Kdo alfa-Kdo-(2->8)-[alfa-Kdo-(2->4)]-alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP
Enzim Chlamydia psittaci prenosi četiri KDO ostatka na lipid A, i formira razgranati tetrasaharid sa strukturom alfa-KDO-(2,8)-[alfa-KDO-(2,4)]-alfa-KDO-(2,4)-alfa-KDO (cf. EC 2.4.99.12 [lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza], EC 2.4.99.13 [(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza], i EC 2.4.99.14 [(KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza]).
Reference[uredi | uredi kod]
- ↑ Brabetz, W., Lindner, B. and Brade, H. (2000). „Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12”. Eur. J. Biochem. 267: 5458-5465. PMID 10951204.
- ↑ Holst, O., Bock, K., Brade, L. and Brade, H. (1995). „The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC”. Eur. J. Biochem. 229: 194-200. PMID 7744029.
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