RNK komponenta telomeraze

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RNK komponenta telomeraze‎

3D reprezentacija dela RNK komponente telomeraze‎. Ovo je rešenje strukture P2b-P3 pseudočvora iz ljudske telomerazne RNK.[1]
Identifikatori
Simboli TERC; DKCA1; PFBMFT2; SCARNA19; TR; TRC3; hTR
Vanjski ID OMIM602322 MGI109558 GeneCards: TERC Gene
Ortolozi
Vrsta Čovek Miš
Entrez 7012 21748
Ensembl ENSG00000200182 ENSMUSG00000064796
UniProt n/a n/a
Ref. Sekv. (iRNK) NR_001566 NR_001579
Ref. Sekv. (protein) n/a n/a
Lokacija (UCSC) Chr 3:
169.48 - 169.48 Mb
Chr 3:
96.22 - 96.22 Mb
PubMed pretraga [1] [2]
Telomerazna RNK kičmenjaka
RF00024.jpg
Identifikatori
Simbol Telomerase-vert
Rfam RF00024
Drugi podaci
RNK tip Gen
Domain(i) Eukariote; Virus
Telomerazna RNK trepljara
RF00025.jpg
Identifikatori
Simbol Telomerase-cil
Rfam RF00025
Drugi podaci
RNK tip Gen
Domain(i) Eukariote
Telomerazna RNK Saccharomyces cerevisiae
RF01050.png
Identifikatori
Simbol Sacc_telomerase
Rfam RF01050
Drugi podaci
RNK tip Gen
Domain(i) Eukariote

RNK komponenta telomeraze, takođe poznata ka TERC, je RNK gen prisutan kod eukariota, koji je komponenta telomeraze, enzima koji produžava telomere.[2][3] TERC služe kao šabloni za telomernu replikaciju (reverznu transkripciju) posredstvom telomeraze. Telomerazne RNK se znatno razlikuju po sekvuenci i strukturi između kičmenjaka, trepljara i kvasaca, mada oni imaju zajedničku strukturu 5' pseudočvora u blizini sekvence šablona. Telomerazna RNA kičmenjaka ima 3' H/ACA domen sličan snoRNK.[4][5][6]

Funkcija[uredi - уреди]

Telomeraza je ribonukleoproteinska polimeraza koja održava telomerne krajeve dodavanjem telomernih ponavljanja TTAGGG. Ovo ponavljanje varira među eukariotama. Enzim se sastoji od proteinske komponente (TERT) sa reverzno transkriptaznom aktivnošću, i RNK komponente, kodirane ovim genom, koja služi kao šablon za telomerno ponavljanje. Izaražavanje telomeraze ima ulogu u ćelijskom starenju, te je normalno zastupljeno u postnatalnim somatskim ćelijama u kojima se javlja progresivno skraćivanje telomera. Deregulacija izražavanja telomeraze u somatskim ćelijama može da doprinese onkogenezi. Studije na miševima sugeriraju da telomeraze takođe učestvuju u hromozomalnoj popravci, pošto do novo sinteze telomernih ponavljanja može doći pri dvolančanim prekidima.[7] Homolozi TERC se takođe mogu naći u Gallid herpes virusima.[8]

Klinički značaj[uredi - уреди]

Mutacije ovog gena uzrokuju autosomalno dominantni diskeratosis kongenita, i mogu da budu asocirane sa delom slučajeva aplastične anemije.[7]

Reference[uredi - уреди]

  1. PDB 1ymo; Theimer CA, Blois CA, Feigon J (2005). "Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.". Mol Cell 17 (5): 671–82. DOI:10.1016/j.molcel.2005.01.017. PMID 15749017. 
  2. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J (September 1995). "The RNA component of human telomerase". Science 269 (5228): 1236–41. DOI:10.1126/science.7544491. PMID 7544491. 
  3. Jády BE, Richard P, Bertrand E, Kiss T (February 2006). "Cell Cycle-dependent Recruitment of Telomerase RNA and Cajal Bodies to Human Telomeres". Mol. Biol. Cell 17 (2): 944–54. DOI:10.1091/mbc.E05-09-0904. PMID 16319170. 
  4. McCormick-Graham, M; Romero DP (1995). "Ciliate telomerase RNA structural features". Nucleic Acids Res 23 (7): 1091–1097. DOI:10.1093/nar/23.7.1091. PMID 7739888. 
  5. Lingner, J; Hendrick LL, Cech TR (1994). "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template". Genes Dev 8 (16): 1984–1998. DOI:10.1101/gad.8.16.1984. PMID 7958872. 
  6. Theimer CA, Feigon J (2006). "Structure and function of telomerase RNA". Curr. Opin. Struct. Biol. 16 (3): 307–18. DOI:10.1016/j.sbi.2006.05.005. PMID 16713250. 
  7. 7.0 7.1 "Entrez Gene: TERC telomerase RNA component". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7012. 
  8. Fragnet, L; Kut E, Rasschaert D (2005). "Comparative functional study of the viral telomerase RNA based on natural mutations". J Biol Chem. 280 (25): 23502–23515. DOI:10.1074/jbc.M501163200. PMID 15811851. 

Literatura[uredi - уреди]

  • de Lange T, Jacks T (1999). "For better or worse? Telomerase inhibition and cancer". Cell 98 (3): 273–5. DOI:10.1016/S0092-8674(00)81955-8. PMID 10458601. 
  • Marrone A, Dokal I (2007). "Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer". Expert reviews in molecular medicine 6 (26): 1–23. DOI:10.1017/S1462399404008671. PMID 15613268. 
  • Yamaguchi H (2007). "Mutations of telomerase complex genes linked to bone marrow failures". Journal of Nippon Medical School = Nihon Ika Daigaku zasshi 74 (3): 202–9. DOI:10.1272/jnms.74.202. PMID 17625368. 
  • Zaug AJ, Linger J, Cech TR (1996). "Method for determining RNA 3' ends and application to human telomerase RNA". Nucleic Acids Res. 24 (3): 532–3. DOI:10.1093/nar/24.3.532. PMID 8602368. 
  • Soder AI (1997). "Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting". Genomics 41 (2): 293–4. DOI:10.1006/geno.1997.4621. PMID 9143511. 
  • Zhao JQ (1998). "Cloning and characterization of human and mouse telomerase RNA gene promoter sequences". Oncogene 16 (10): 1345–50. DOI:10.1038/sj.onc.1201892. PMID 9546436. 
  • Mitchell JR, Wood E, Collins K (1999). "A telomerase component is defective in the human disease dyskeratosis congenita". Nature 402 (6761): 551–5. DOI:10.1038/990141. PMID 10591218. 
  • Chen JL, Blasco MA, Greider CW (2000). "Secondary structure of vertebrate telomerase RNA". Cell 100 (5): 503–14. DOI:10.1016/S0092-8674(00)80687-X. PMID 10721988. 
  • Wong KK (2000). "Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation". Nat. Genet. 26 (1): 85–8. DOI:10.1038/79232. PMID 10973255. 
  • Mitchell JR, Collins K (2000). "Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase". Mol. Cell 6 (2): 361–71. DOI:10.1016/S1097-2765(00)00036-8. PMID 10983983. 
  • Imoto I (2001). "SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus". Biochem. Biophys. Res. Commun. 286 (3): 559–65. DOI:10.1006/bbrc.2001.5428. PMID 11511096. 
  • Vulliamy T (2001). "The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita". Nature 413 (6854): 432–5. DOI:10.1038/35096585. PMID 11574891. 
  • Pruzan R (2002). "Allosteric inhibitors of telomerase: oligonucleotide N3′→P5′ phosphoramidates". Nucleic Acids Res. 30 (2): 559–68. DOI:10.1093/nar/30.2.559. PMID 11788719. 
  • Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Res. 12 (1): 55–62. DOI:10.1038/sj.cr.7290110. PMID 11942411. 
  • Yang Y (2002). "Nucleolar localization of hTERT protein is associated with telomerase function". Exp. Cell Res. 277 (2): 201–9. DOI:10.1006/excr.2002.5541. PMID 12083802. 
  • Chang JT (2002). "Differential regulation of telomerase activity by six telomerase subunits". Eur. J. Biochem. 269 (14): 3442–50. DOI:10.1046/j.1432-1033.2002.03025.x. PMID 12135483. 
  • Gavory G, Farrow M, Balasubramanian S (2002). "Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro". Nucleic Acids Res. 30 (20): 4470–80. DOI:10.1093/nar/gkf575. PMID 12384594. 
  • Sood AK (2003). "p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma". Cancer Biol. Ther. 1 (5): 511–7. PMID 12496479. 
  • Antal, M; Boros E, Solymosy F, Kiss T (2002). "Analysis of the structure of human telomerase RNA in vivo". Nucleic Acids Res 30 (4): 912–920. DOI:10.1093/nar/30.4.912. PMID 11842102. 

Vanjske veze[uredi - уреди]