RFC3
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| Replikacioni faktor C (aktivator 1) 3, 38kDa | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | RFC3; RFC38 | ||||||||||
| Vanjski ID | OMIM: 600405 MGI: 1916513 HomoloGene: 2188 GeneCards: RFC3 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5983 | 69263 | |||||||||
| Ensembl | ENSG00000133119 | ENSMUSG00000033970 | |||||||||
| UniProt | P40938 | Q8R323 | |||||||||
| Ref. Sekv. (iRNK) | NM_002915 | NM_027009 | |||||||||
| Ref. Sekv. (protein) | NP_002906 | NP_081285 | |||||||||
| Lokacija (UCSC) | Chr 13: 34.39 - 34.54 Mb | Chr 5: 151.64 - 151.65 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Replikacioni faktor C, podjedinica 3 je protein koji je kod ljudi kodiran RFC3 genom.[1][2]
Za elongaciju prajmiranog DNK šablona DNK polimerazom delta i DNK polimerazom epsilon neophodni su pomoćni proteini: proliferativni ćelijski nuklearni antigen (PCNA) i replikacioni faktor C (RFC). RFC, takođe poznat kao aktivator 1, je proteinski kompleks koji se sastoji od pet podjedinica sa 140, 40, 38, 37, i 36 kDa. Ovaj gen kodira 38 kDa podjednicu. Ta podjedinica je esencijalna za interakciju između 140 kDa podjedinice i srži kompleksa koja se sastoji od 36, 37, i 40 kDa podjedinica. Poznate su alternativno splajsovane transcriptne varijante koje kodiraju različite izoforme.[2]
Interakcije[uredi | uredi kod]
RFC3 formira interakcije sa BRD4,[3] CHTF18,[4][5] RFC1,[6][7][8] PCNA[5][9] i RFC4.[6][7]
Reference[uredi | uredi kod]
- ↑ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K, et al. (Jul 1995). „Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23”. Genomics 25 (1): 274–8. DOI:10.1016/0888-7543(95)80135-9. PMID 7774928.
- ↑ 2,0 2,1 „Entrez Gene: RFC3 replication factor C (activator 1) 3, 38kDa”.
- ↑ Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. (United States) 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. ISSN 0270-7306. PMC 135621. PMID 12192049.
- ↑ Bermudez, Vladimir P; Maniwa Yoshimasa, Tappin Inger, Ozato Keiko, Yokomori Kyoko, Hurwitz Jerard (Sep 2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. DOI:10.1073/pnas.1434308100. ISSN 0027-8424. PMC 193545. PMID 12930902.
- ↑ 5,0 5,1 Merkle, Carolin J; Karnitz Larry M, Henry-Sánchez John T, Chen Junjie (Aug 2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment”. J. Biol. Chem. (United States) 278 (32): 30051–6. DOI:10.1074/jbc.M211591200. ISSN 0021-9258. PMID 12766176.
- ↑ 6,0 6,1 Ellison, V; Stillman B (Mar 1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity”. J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. ISSN 0021-9258. PMID 9488738.
- ↑ 7,0 7,1 Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). „In vitro reconstitution of human replication factor C from its five subunits”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. ISSN 0027-8424. PMC 39056. PMID 8692848.
- ↑ Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr 2008). „DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex”. J. Biol. Chem. (United States) 283 (14): 9071–9. DOI:10.1074/jbc.M709835200. ISSN 0021-9258. PMC 2431014. PMID 18245774.
- ↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. (United States) 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929.
Literatura[uredi | uredi kod]
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1-2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- O'Donnell M, Onrust R, Dean FB, et al. (1993). „Homology in accessory proteins of replicative polymerases--E. coli to humans.”. Nucleic Acids Res. 21 (1): 1–3. DOI:10.1093/nar/21.1.1. PMC 309057. PMID 8441605.
- Uhlmann F, Cai J, Flores-Rozas H, et al. (1996). „In vitro reconstitution of human replication factor C from its five subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. DOI:10.1073/pnas.93.13.6521. PMC 39056. PMID 8692848.
- Uhlmann F, Cai J, Gibbs E, et al. (1997). „Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities.”. J. Biol. Chem. 272 (15): 10058–64. DOI:10.1074/jbc.272.15.10058. PMID 9092549.
- Cujec TP, Cho H, Maldonado E, et al. (1997). „The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.”. Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429.
- Cai J, Gibbs E, Uhlmann F, et al. (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme.”. J. Biol. Chem. 272 (30): 18974–81. DOI:10.1074/jbc.272.30.18974. PMID 9228079.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene 200 (1-2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Ellison V, Stillman B (1998). „Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity.”. J. Biol. Chem. 273 (10): 5979–87. DOI:10.1074/jbc.273.10.5979. PMID 9488738.
- Zhang G, Gibbs E, Kelman Z, et al. (1999). „Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen.”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. DOI:10.1073/pnas.96.5.1869. PMC 26703. PMID 10051561.
- Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000). „The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.”. J. Biol. Chem. 275 (38): 29767–71. DOI:10.1074/jbc.M005782200. PMID 10884395.
- Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). „Purification and characterization of human DNA damage checkpoint Rad complexes.”. Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. DOI:10.1073/pnas.201373498. PMC 58713. PMID 11572977.
- Griffith JD, Lindsey-Boltz LA, Sancar A (2002). „Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.”. J. Biol. Chem. 277 (18): 15233–6. DOI:10.1074/jbc.C200129200. PMID 11907025.
- Ohta S, Shiomi Y, Sugimoto K, et al. (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.”. J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929.
- Maruyama T, Farina A, Dey A, et al. (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.”. Mol. Cell. Biol. 22 (18): 6509–20. DOI:10.1128/MCB.22.18.6509-6520.2002. PMC 135621. PMID 12192049.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.”. J. Biol. Chem. 278 (32): 30051–6. DOI:10.1074/jbc.M211591200. PMID 12766176.
- Bermudez VP, Maniwa Y, Tappin I, et al. (2003). „The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.”. Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237–42. DOI:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
- Zou L, Liu D, Elledge SJ (2004). „Replication protein A-mediated recruitment and activation of Rad17 complexes.”. Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13827–32. DOI:10.1073/pnas.2336100100. PMC 283506. PMID 14605214.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.