POLD2

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Polimeraza (DNK vođena), delta 2, pomoćna podjedinica
Dostupne strukture
3E0J
Identifikatori
Simbol POLD2
Vanjski ID OMIM600815 MGI1097163 HomoloGene4538 GeneCards: POLD2 Gene
EC broj 2.7.7.7
Pregled RNK izražavanja
PBB GE POLD2 201115 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5425 18972
Ensembl ENSG00000106628 ENSMUSG00000020471
UniProt P49005 O35654
Ref. Sekv. (iRNK) NM_001127218 NM_008894
Ref. Sekv. (protein) NP_001120690 NP_032920
Lokacija (UCSC) Chr 7:
44.15 - 44.16 Mb
Chr 11:
5.87 - 5.88 Mb
PubMed pretraga [1] [2]

Delta podjedinica 2 DNK polimeraze je enzim koji je kod ljudi kodiran POLD2 genom.[1][2] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije[uredi - уреди]

POLD2 formira interakcije sa PCNA.[3]

Reference[uredi - уреди]

  1. Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics 29 (1): 179–86. DOI:10.1006/geno.1995.1229. PMID 8530069. 
  2. "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5425. 
  3. Lu, Xiaoqing; Tan Cheng-Keat, Zhou Jin-Qiu, You Min, Carastro L Michael, Downey Kathleen M, So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. DOI:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310. 

Literatura[uredi - уреди]

  • Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).". Genomics 44 (1): 45–51. DOI:10.1006/geno.1997.4838. PMID 9286699. 
  • Hisama FM (2000). "WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts". Cancer Res. 60 (9): 2372–6. PMID 10811112. 
  • Mo J (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry 39 (24): 7245–54. DOI:10.1021/bi0000871. PMID 10852724. 
  • Perez A, Leon A, Lee MY (2000). "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta". Biochim. Biophys. Acta 1493 (1–2): 231–6. DOI:10.1016/s0167-4781(00)00153-6. PMID 10978529. 
  • Szekely AM (2000). "Werner protein recruits DNA polymerase δ to the nucleolus". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. DOI:10.1073/pnas.97.21.11365. PMID 11027336. 
  • He H, Tan CK, Downey KM, So AG (2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. DOI:10.1073/pnas.221452098. PMID 11593007. 
  • Lu X (2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. DOI:10.1074/jbc.M200065200. PMID 11986310. 
  • Ohta S (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. DOI:10.1074/jbc.M206194200. PMID 12171929. 
  • Strausberg RL (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Liu L (2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J. Biol. Chem. 278 (12): 10041–7. DOI:10.1074/jbc.M208694200. PMID 12522211. 
  • Scherer SW (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMID 12690205. 
  • Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. DOI:10.1101/gr.2122004. PMID 15231747. 
  • Gerhard DS (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334. 
  • Tsurimoto T (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells 10 (1): 13–22. DOI:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. 
  • Rual JF (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.