POLD3

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Polimeraza (DNK vođena), delta 3, pomoćna jedinica

Prikaz POLD3 baziran na PDB 1U76
Dostupne strukture
1U76, 3E0J
Identifikatori
Simboli POLD3; P66; P68
Vanjski ID OMIM611415 MGI1915217 HomoloGene38202 GeneCards: POLD3 Gene
Pregled RNK izražavanja
PBB GE POLD3 212836 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 10714 67967
Ensembl ENSG00000077514 ENSMUSG00000030726
UniProt Q15054 Q9EQ28
Ref. Sekv. (iRNK) NM_006591 NM_133692
Ref. Sekv. (protein) NP_006582 NP_598453
Lokacija (UCSC) Chr 11:
74.2 - 74.38 Mb
Chr 7:
100.08 - 100.12 Mb
PubMed pretraga [1] [2]

Delta podjedinica 3 DNK polimeraze je enzim koji je kod ljudi kodiran POLD3 genom.[1][2] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije[uredi - уреди]

POLD3 formira interakcije sa PCNA.[3][4]

Reference[uredi - уреди]

  1. Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083. 
  2. "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10714. 
  3. Ducoux, M; Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. (United States) 276 (52): 49258–66. doi:10.1074/jbc.M106990200. ISSN 0021-9258. PMID 11595739. 
  4. Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. doi:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929. 

Literatura[uredi - уреди]