Timin-DNK glikozilaza
(Preusmjereno sa stranice Za neusklađenost specifična timin-DNK glikozilaza)
| Timin-DNK glikozilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.2.2.29 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Timin-DNK glikozilaza (EC 3.2.2.29, za neusklađenost specifična timin-DNK glikozilaza, za neusklađenost specifična timin-DNK N-glikozilaza, hTDG, hsTDG, TDG, timinska DNK glikozilaza, G/T glikozilaza, uracil/timin DNK glikozilaza, T:G za neusklađenost specifična timidin-DNK glikozilaza, G:T za neusklađenost specifična timinska DNK-glikozilaza) je enzim sa sistematskim imenom timin-DNK dezoksiribohidrolaza (otpuštanje timina).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa timin
Zimin-DNK glikozilaza je deo mehanizma za popravku DNK.
- ↑ Waters, T.R. and Swann, P.F. (2000). „Thymine-DNA glycosylase and G to A transition mutations at CpG sites”. Mutat. Res. 462: 137-147. PMID 10767625.
- ↑ Neddermann, P. and Jiricny, J. (1993). „The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells”. J. Biol. Chem. 268: 21218-21224. PMID 8407958.
- ↑ Waters, T.R. and Swann, P.F. (1998). „Kinetics of the action of thymine DNA glycosylase”. J. Biol. Chem. 273: 20007-20014. PMID 9685338.
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