GDP-L-galaktoza fosforilaza
(Preusmjereno sa stranice VTC2)
| GDP-L-galaktoza fosforilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.69 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
GDP-L-galaktoza fosforilaza (EC 2.7.7.69, VTC2, VTC5) je enzim sa sistematskim imenom GDP:alfa-L-galaktoza 1-fosfat guanililtransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-L-galaktoza + fosfat alfa-L-galaktoza 1-fosfat + GDP
Ovaj enzim katalizuje jednu od reakcija u Smirnof-Vilerovom putu, koji je glavni put biosinteze askorbata kod biljki.
Reference[uredi | uredi kod]
- ↑ Linster, C.L., Gomez, T.A., Christensen, K.C., Adler, L.N., Young, B.D., Brenner, C. and Clarke, S.G. (2007). „Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants”. J. Biol. Chem. 282: 18879-18885. PMID 17462988.
- ↑ Linster, C.L., Adler, L.N., Webb, K., Christensen, K.C., Brenner, C. and Clarke, S.G. (2008). „A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction”. J. Biol. Chem. 283: 18483-18492. PMID 18463094.
- ↑ Dowdle, J., Ishikawa, T., Gatzek, S., Rolinski, S. and Smirnoff, N. (2007). „Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability”. Plant J. 52: 673-689. PMID 17877701.
- ↑ Muller-Moule, P. (2008). „An expression analysis of the ascorbate biosynthesis enzyme VTC2”. Plant Mol. Biol. 68: 31-41. PMID 18516687.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.