TRNK (citidin56-2'-O)-metiltransferaza
(Preusmjereno sa stranice TRNA ribose 2'-O-methyltransferase aTrm56)
| TRNK (citidin56-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.206 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK (citidin56-2'-O)-metiltransferaza (EC 2.1.1.206, aTrm56, tRNK riboza 2'-O-metiltransferaza aTrm56, PAB1040 (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (citidin56-2'-O)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + citidin56 u tRNK S-adenozil-L-homocistein + 2'-O-metilcitidin56 u tRNK
Arhejski enzim specifično katalizuje S-adenozil-L-metionin zavisnu 2'-O-riboznu metilaciju citidina u poziciji 56 na tRNK transkriptima.
Reference[uredi | uredi kod]
- ↑ Renalier, M.H., Joseph, N., Gaspin, C., Thebault, P. and Mougin, A. (2005). „The Cm56 tRNA modification in archaea is catalyzed either by a specific 2′-O-methylase, or a C/D sRNP”. RNA 11: 1051-1063. PMID 15987815.
- ↑ Kuratani, M., Bessho, Y., Nishimoto, M., Grosjean, H. and Yokoyama, S. (2008). „Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2′-O-methylcytidine at position 56 of tRNA”. J. Mol. Biol. 375: 1064-1075. PMID 18068186.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.