TRNK (adenin22-N1)-metiltransferaza
(Preusmjereno sa stranice TRNA (adenine22-N1)-methyltransferase)
| TRNK (adenin22-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.217 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK (adenin22-N1)-metiltransferaza (EC 2.1.1.217, TrmK, YqfN, Sp1610 (gen), tRNK: m1A22 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin22-N1)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + adenin22 u tRNK S-adenozil-L-homocistein + N1-metiladenin22 u tRNK
Ovaj enzim specifično metiluje adenin22 u tRNK.
Reference[uredi | uredi kod]
- ↑ Ta, H.M. and Kim, K.K. (2010). „Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine”. Protein Sci. 19: 617-624. PMID 20052680.
- ↑ Roovers, M., Kaminska, K.H., Tkaczuk, K.L., Gigot, D., Droogmans, L. and Bujnicki, J.M. (2008). „The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK)”. Nucleic Acids Res. 36: 3252-3262. PMID 18420655.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.