FMN reduktaza (NADPH)
(Preusmjereno sa stranice SsuE)
| FMN reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.1.38 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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FMN reduktaza (NADPH) (EC 1.5.1.38, FRP, flavinska reduktaza P, SsuE) je enzim sa sistematskim imenom FMNH2:NADP+ oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- FMNH2 + NADP+ FMN + NADPH + H+
Enzimi iz bioluminescentih bakterija sadrže FMN, za razliku od enzima iz Escherichia coli.
Reference[uredi | uredi kod]
- ↑ Gerlo, E. and Charlier, J. (1975). „Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi”. Eur. J. Biochem. 57: 461-467. PMID 1175652.
- ↑ Jablonski, E. and DeLuca, M. (1977). „Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi”. Biochemistry 16: 2932-2936. PMID 880288.
- ↑ Jablonski, E. and DeLuca, M. (1978). „Studies of the control of luminescence in Beneckea harveyi: properties of the NADH and NADPH:FMN oxidoreductases”. Biochemistry 17: 672-678. PMID 23827.
- ↑ Lei, B., Liu, M., Huang, S. and Tu, S.C. (1994). „Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme”. J. Bacteriol. 176: 3552-3558. PMID 8206832.
- ↑ Tanner, J.J., Lei, B., Tu, S.C. and Krause, K.L. (1996). „Flavin reductase P: structure of a dimeric enzyme that reduces flavin”. Biochemistry 35: 13531-13539. PMID 8885832.
- ↑ Liu, M., Lei, B., Ding, Q., Lee, J.C. and Tu, S.C. (1997). „Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium”. Arch. Biochem. Biophys. 337: 89-95. PMID 8990272.
- ↑ Lei, B. and Tu, S.C. (1998). „Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase”. Biochemistry 37: 14623-14629. PMID 9772191.
- ↑ Eichhorn, E., van der Ploeg, J.R. and Leisinger, T. (1999). „Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli”. J. Biol. Chem. 274: 26639-26646. PMID 10480865.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.