Rodopsin kinaza
| Rodopsin kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.14 | ||||||||
| CAS broj | 54004-64-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Rodopsin kinaza (EC 2.7.11.14, kupasti opsin kinaza, G-protein-spregnuti receptor kinaza 1, GPCR kinaza 1, GRK1, GRK7, opsinska kinaza, opsinska kinaza (fosforilacija), rodopsinska kinaza (fosforilacija), RK, STK14) je enzim sa sistematskim imenom ATP:rodopsin fosfotransferaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + rodopsin ADP + fosforhodopsin
G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).
- ↑ Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). „Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase”. Nature 321: 869-872. PMID 3014340.
- ↑ Shichi, H. and Somers, R.L. (1978). „Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase”. J. Biol. Chem. 253: 7040-7046. PMID 690139.
- ↑ Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). „Purification and characterization of rhodopsin kinase”. J. Biol. Chem. 263: 14067-14073. PMID 2844754.
- ↑ Weller, M., Virmaux, N. and Mandel, P. (1975). „Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin”. Proc. Natl. Acad. Sci. USA 72: 381-385. PMID 164024.
- ↑ Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). „Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications”. Proc. Natl. Acad. Sci. USA 94: 10577-10582. PMID 9380677.
- ↑ Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). „Characterization and chromosomal localization of the gene for human rhodopsin kinase”. Genomics 35: 571-576. PMID 8812493.
- ↑ Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). „Characterization of human GRK7 as a potential cone opsin kinase”. Mol. Vis. 7: 305-313. PMID 11754336.
- ↑ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626-633. PMID 14654303.
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