23S rRNK pseudouridinska955/2504/2580 sintaza
(Preusmjereno sa stranice RluC)
| 23S rRNK pseudouridinska955/2504/2580 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.24 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
23S rRNK pseudouridinska955/2504/2580 sintaza (EC 5.4.99.24, RluC, pseudouridinska sintaza RluC) je enzim sa sistematskim imenom 23S rRNK-uridin955/2504/2580 uracil mutaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 23S rRNK uridin955/uridin2504/uridin2580 23S rRNK pseudouridin955/pseudouridin2504/pseudouridin2580
Ovaj enzim konvertuje uridine u pozicijama 955, 2504 i 2580 molekula 23S rRNK u pseudouridine.
Reference[uredi | uredi kod]
- ↑ Jiang, M., Sullivan, S.M., Walker, A.K., Strahler, J.R., Andrews, P.C. and Maddock, J.R. (2007). „Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques”. J. Bacteriol. 189: 3434-3444. PMID 17337586.
- ↑ Conrad, J., Sun, D., Englund, N. and Ofengand, J. (1998). „The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA”. J. Biol. Chem. 273: 18562-18566. PMID 9660827.
- ↑ Corollo, D., Blair-Johnson, M., Conrad, J., Fiedler, T., Sun, D., Wang, L., Ofengand, J. and Fenna, R. (1999). „Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli”. Acta Crystallogr. D Biol. Crystallogr. 55: 302-304. PMID 10089432.
- ↑ Toh, S.M. and Mankin, A.S. (2008). „An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors”. J. Mol. Biol. 380: 593-597. PMID 18554609.
Literatura[uredi | uredi kod]
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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