OR1D2
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| Olfaktorni receptor, familija 1, potfamilija D, član 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OR1D2; OLFR1; OR17-4 | ||||||||||
| Vanjski ID | OMIM: 164342 MGI: 3030246 HomoloGene: 37634 GeneCards: OR1D2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4991 | 258153 | |||||||||
| Ensembl | ENSG00000184166 | ENSMUSG00000058275 | |||||||||
| UniProt | P34982 | Q7TRW7 | |||||||||
| RefSeq (mRNA) | NM_002548.2 | NM_001011851.1 | |||||||||
| RefSeq (protein) | NP_002539.2 | NP_001011851.1 | |||||||||
| Lokacija (UCSC) | Chr 17: 3 - 3 Mb | Chr 11: 74.36 - 74.37 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 1D1 je protein koji je kod ljudi kodiran OR1D1 genom.[1][2][3]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[3]
Reference[uredi - уреди | uredi izvor]
- ↑ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature 355 (6359): 453–5. PMID 1370859. doi:10.1038/355453a0. Check date values in:
|date=(help) - ↑ Buck L, Axel R (May 1991). "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition". Cell 65 (1): 175–87. PMID 1840504. doi:10.1016/0092-8674(91)90418-X.
- ↑ 3,0 3,1 "Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4991.
Literatura[uredi - уреди | uredi izvor]
- Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J (1992). "Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences.". Brain Res. Mol. Brain Res. 13 (1–2): 159–63. PMID 1315913. doi:10.1016/0169-328X(92)90057-I.
- Ben-Arie N, Lancet D, Taylor C et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. PMID 8004088. doi:10.1093/hmg/3.2.229.
- Schurmans S, Muscatelli F, Miot F et al. (1993). "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism". Cytogenet. Cell Genet. 63 (3): 200–4. PMID 8097991. doi:10.1159/000133534.
- Nekrasova E, Sosinskaya A, Natochin M et al. (1996). "Overexpression, solubilization and purification of rat and human olfactory receptors". Eur. J. Biochem. 238 (1): 28–37. PMID 8665947. doi:10.1111/j.1432-1033.1996.0028q.x.
- Glusman G, Sosinsky A, Ben-Asher E et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics 63 (2): 227–45. PMID 10673334. doi:10.1006/geno.1999.6030.
- Fuchs T, Malecova B, Linhart C et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics 80 (3): 295–302. PMID 12213199. doi:10.1006/geno.2002.6830.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Spehr M, Gisselmann G, Poplawski A et al. (2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science 299 (5615): 2054–8. PMID 12663925. doi:10.1126/science.1080376.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. PMC 356993. PMID 14983052. doi:10.1073/pnas.0307882100.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
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