OR3A1
(Preusmjereno sa stranice OLFRA03)
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| Olfaktorni receptor, familija 3, potfamilija A, član 1 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OR3A1; OLFRA03; OR17-40; OR17-82; OR40 | ||||||||||
| Vanjski ID | MGI: 3030236 HomoloGene: 1915 GeneCards: OR3A1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4994 | 258703 | |||||||||
| Ensembl | ENSG00000180090 | ENSMUSG00000070379 | |||||||||
| UniProt | P47881 | Q8VFX7 | |||||||||
| RefSeq (mRNA) | NM_002550.2 | NM_146708.1 | |||||||||
| RefSeq (protein) | NP_002541.2 | NP_666919.1 | |||||||||
| Lokacija (UCSC) | Chr 17: 3.19 - 3.2 Mb | Chr 11: 74.16 - 74.16 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Olfaktorni receptor 3A1 je protein koji je kod ljudi kodiran OR3A1 genom.[1][2][3]
Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.[3]
Reference[uredi | uredi kod]
- ↑ Glusman G, Clifton S, Roe B, Lancet D (Feb 1997). „Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity”. Genomics 37 (2): 147–60. DOI:10.1006/geno.1996.0536. PMID 8921386.
- ↑ Crowe ML, Perry BN, Connerton IF (Jul 1996). „Olfactory receptor-encoding genes and pseudogenes are expressed in humans”. Gene 169 (2): 247–9. DOI:10.1016/0378-1119(95)00849-7. PMID 8647456.
- ↑ 3,0 3,1 „Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1”.
Literatura[uredi | uredi kod]
- Marrakchi M, Vidic J, Jaffrezic-Renault N, et al. (2008). „A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40”. Eur. Biophys. J. 36 (8): 1015–8. DOI:10.1007/s00249-007-0187-6. PMID 17579849.
- Jacquier V, Prummer M, Segura JM, et al. (2006). „Visualizing odorant receptor trafficking in living cells down to the single-molecule level”. Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14325–30. DOI:10.1073/pnas.0603942103. PMC 1599963. PMID 16980412.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. DOI:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). „Sequence, structure, and evolution of a complete human olfactory receptor gene cluster”. Genomics 63 (2): 227–45. DOI:10.1006/geno.1999.6030. PMID 10673334.
- Ben-Arie N, Lancet D, Taylor C, et al. (1994). „Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire”. Hum. Mol. Genet. 3 (2): 229–35. DOI:10.1093/hmg/3.2.229. PMID 8004088.