18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza
(Preusmjereno sa stranice M2(6)A dimetilaza)
| 18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.183 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza (EC 2.1.1.183, 18S rRNK dimetilaza Dim1p, Dim1p, ScDim1, m2(6)A dimetilaza, KIDIM1) je enzim sa sistematskim imenom S-adenozil-L-metionin:18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4 S-adenozil-L-metionin + adenin1779/adenin1780 u 18S rRNK 4 S-adenozil-L-homocistein + N6-dimetiladenin1779/N6-dimetiladenin1780 u 18S rRNK
DIM1 učestvuje u pre-rRNK transformacijama.
Reference[uredi | uredi kod]
- ↑ Lafontaine, D., Vandenhaute, J. and Tollervey, D. (1995). „The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast”. Genes Dev. 9: 2470-2481. PMID 7590228.
- ↑ Lafontaine, D.L., Preiss, T. and Tollervey, D. (1998). „Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis”. Mol. Cell Biol. 18: 2360-2370. PMID 9528805.
- ↑ Pulicherla, N., Pogorzala, L.A., Xu, Z., O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M. and Rife, J.P. (2009). „Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases”. J. Mol. Biol. 391: 884-893. PMID 19520088.
- ↑ Lafontaine, D., Delcour, J., Glasser, A.L., Desgres, J. and Vandenhaute, J. (1994). „The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast”. J. Mol. Biol. 241: 492-497. PMID 8064863.
- ↑ O'Farrell, H.C., Pulicherla, N., Desai, P.M. and Rife, J.P. (2006). „Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution”. RNA 12: 725-733. PMID 16540698.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.