Lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza
(Preusmjereno sa stranice KDO transferase)
| Lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.12 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza (EC 2.4.99.12, KDO transferaza, waaA (gen), kdtA (gen), 3-dezoksi-D-mano-okt-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza, lipid IVA KDO transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-oct-2-ulozonat:lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- lipid IVA + CMP-alfa-Kdo alfa-Kdo-(2->6)-lipid IVA + CMP
Ovaj bifunkcionalani enzim iz Escherichia coli prenosi dva 3-dezoksi-D-mano-okt-2-ulozonatna ostataka na lipid IVA (cf. EC 2.4.99.13 [(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza]).
Reference[uredi | uredi kod]
- ↑ Belunis, C.J. and Raetz, C.R. (1992). „Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli”. J. Biol. Chem. 267: 9988-9997. PMID 1577828.
- ↑ Mamat, U., Schmidt, H., Munoz, E., Lindner, B., Fukase, K., Hanuszkiewicz, A., Wu, J., Meredith, T.C., Woodard, R.W., Hilgenfeld, R., Mesters, J.R. and Holst, O. (2009). „WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis”. J. Biol. Chem. 284: 22248-22262. PMID 19546212.
- ↑ White, K.A., Kaltashov, I.A., Cotter, R.J. and Raetz, C.R. (1997). „A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae”. J. Biol. Chem. 272: 16555-16563. PMID 9195966.
- ↑ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391-399. PMID 8748024.
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