Peptidoglikan-N-acetilglukozaminska deacetilaza
(Preusmjereno sa stranice HP310)
| Peptidoglikan-N-acetilglukozaminska deacetilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.104 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Peptidoglikan-N-acetilglukozaminska deacetilaza (EC 3.5.1.104, HP310, PgdA, SpPgdA, BC1960, peptidoglikanska deacetilaza, peptidoglikan GlcNAc deacetilaza, peptidoglikan N-acetilglukozaminska deacetilaza, PG N-deacetilaza) je enzim sa sistematskim imenom peptidoglikan-N-acetilglukozamin amidohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- peptidoglikan-N-acetil-D-glukozamin + H2O peptidoglikan-D-glukozamin + acetat
Modifikacija peptidoglikana N-deacetilacijom je važan faktor virulencije Helicobacter pylori, Listeria monocytogenes i Streptococcus suis vrsta.
Reference[uredi | uredi kod]
- ↑ Psylinakis, E., Boneca, I.G., Mavromatis, K., Deli, A., Hayhurst, E., Foster, S.J., Varum, K.M. and Bouriotis, V. (2005). „Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis”. J. Biol. Chem. 280: 30856-30863. PMID 15961396.
- ↑ Tsalafouta, A., Psylinakis, E., Kapetaniou, E.G., Kotsifaki, D., Deli, A., Roidis, A., Bouriotis, V. and Kokkinidis, M. (2008). „Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 203-205. PMID 18323609.
- ↑ Blair, D.E., Schuttelkopf, A.W., MacRae, J.I. and van Aalten, D.M. (2005). „Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor”. Proc. Natl. Acad. Sci. USA 102: 15429-15434. PMID 16221761.
- ↑ Wang, G., Olczak, A., Forsberg, L.S. and Maier, R.J. (2009). „Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori”. J. Biol. Chem. 284: 6790-6800. PMID 19147492.
- ↑ Popowska, M., Kusio, M., Szymanska, P. and Markiewicz, Z. (2009). „Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis”. J. Microbiol. Biotechnol. 19: 932-945. PMID 19809250.
- ↑ Fittipaldi, N., Sekizaki, T., Takamatsu, D., de la Cruz Domínguez-Punaro, M., Harel, J., Bui, N.K., Vollmer, W. and Gottschalk, M. (2008). „Significant contribution of the pgdA gene to the virulence of Streptococcus suis”. Mol. Microbiol. 70: 1120-1135. PMID 18990186.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.