7-Alfa-hidroksiholest-4-en-3-on 12-alfa-hidroksilaza
(Preusmjereno sa stranice HCO 12alpha-hydroxylase)
| 7-Alfa-hidroksiholest-4-en-3-on 12-alfa-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.95 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
7-Alfa-hidroksiholest-4-en-3-on 12-alfa-hidroksilaza (EC 1.14.13.95, 7alfa-hidroksi-4-holesten-3-on 12alfa-monooksigenaza, CYP12, sterol 12alfa-hidroksilaza (nespecifična), HCO 12alfa-hidroksilaza) je enzim sa sistematskim imenom 7alfa-hidroksiholest-4-en-3-on,NADPH:kiseonik oksidoreduktaza (12alfa-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 7alfa-hidroksicholest-4-en-3-on + NADPH + H+ + O2 7alfa,12alfa-dihidroksicholest-4-en-3-on + NADP+ +H2O
Ovaj enzim jehem-tiolatni protein (P-450).
- ↑ Ishida, H., Noshiro, M., Okuda, K. and Coon, M.J. (1992). „Purification and characterization of 7α-hydroxy-4-cholesten-3-one 12α-hydroxylase”. J. Biol. Chem. 267: 21319-21323. PMID 1400444.
- ↑ Eggertsen, G., Olin, M., Andersson, U., Ishida, H., Kubota, S., Hellman, U., Okuda, K.I. and Björkhem, I. (1996). „Molecular cloning and expression of rabbit sterol 12α-hydroxylase”. J. Biol. Chem. 271: 32269-32275. PMID 8943286.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.