Glukozil-3-fosfogliceratna fosfataza
(Preusmjereno sa stranice GpgP protein)
| Glukozil-3-fosfogliceratna fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.85 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glukozil-3-fosfogliceratna fosfataza (EC 3.1.3.85, GpgP protein) je enzim sa sistematskim imenom alfa-D-glukozil-3-fosfo-D-glicerat fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-O-(alfa-D-glukopiranozil)-3-fosfo-D-glicerat + H2O 2-O-(alfa-D-glukopiranozil)-D-glicerat + fosfat
Ovaj enzim učestvuje u biosintezi 2-O-(alfa-D-glukopiranozil)-D-glicerata putem dva stupnja u kojima enzim EC 2.4.1.266 (glukozil-3-fosfoglicerat sintaza) katalizuje konverziju GDP-glukoze i 3-fosfo-D-glicerata u 2-O-(alfa-D-glukopiranozil)-3-fosfo-D-glicerat, koji se zatim konvertuju u 2-O-(alfa-D-glukopiranozil)-D-glicerat posredtvom glukozil-3-fosfoglicerat fosfataze.
Reference[uredi | uredi kod]
- ↑ Costa, J., Empadinhas, N. and da Costa, M.S. (2007). „Glucosylglycerate biosynthesis in the deepest lineage of the bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina”. J. Bacteriol. 189: 1648-1654. PMID 17189358.
- ↑ Costa, J., Empadinhas, N., Goncalves, L., Lamosa, P., Santos, H. and da Costa, M.S. (2006). „Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii”. J. Bacteriol. 188: 1022-1030. PMID 16428406.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.