2-Aminoizobuterna kiselina

2-Aminoizobuterna kiselina
	2-Amino-2-metilpropanoinska kiselina
Drugi nazivi	α-Aminoizobuterna kiselina; 2-Metilalanin
Identifikacija
CAS registarski broj	62-57-7
PubChem	6119
ChemSpider	5891
EC-broj	200-544-0
DrugBank	DB02952
KEGG	C03665
ChEBI	27971
Jmol-3D slike	Slika 1
SMILES
	O=C(O)C(N)(C)C
InChI
	InChI=1S/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7) ; Kod: FUOOLUPWFVMBKG-UHFFFAOYSA-N InChI=1/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7); Kod: FUOOLUPWFVMBKG-UHFFFAOYAD
Svojstva
Molekulska formula	C4H9NO2
Molarna masa	103.12 g mol−1
Agregatno stanje	bela kristalna materija
Gustina	1,09 g/mL
Tačka ključanja	204.4 °C, 478 K, 400 °F
Rastvorljivost u vodi	rastvoran je
pKa	2,36 (karboksil), 10,21 (amino)
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

2-Aminoizobuterna kiselina, očo α-aminoizobuterna kiselina (AIB) ili α-metilalanin ili 2-metilalanin, je aminokiselina sa strukturnom formulom H₂N-C(CH₃)₂-COOH. Ona je komponenta pojedinih antibiotika fungalnog porekla, e.g. alameticin i pojedinih lantibiotika. Ona se ne ubraja u proteinogene aminokiseline i retko se javlja u prirodi. α-Aminoizobuterna kiselina indukuje formiranje heliksa kod peptida. Njeni oligomeri formiraju 3-10 helikse.

U laboratoriji se 2-aminoizobuterna kiselina može pripremiti iz aceton cijanohidrina, reakcijom sa amonijakom, čemu sledi hidroliza.^[6]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Dawson, R.M.C., et al., Data for Biochemical Research, Oxford, Clarendon Press, 1959.
↑ Clarke, H. T.; Bean, H. J. (1931), „α-Aminoisobutyric acid”, Organic Syntheses 11: 4 ; Coll. Vol. 2: 29 .

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Dawson, R.M.C., et al., Data for Biochemical Research, Oxford, Clarendon Press, 1959.

[6] Clarke, H. T.; Bean, H. J. (1931), „α-Aminoisobutyric acid”, Organic Syntheses 11: 4 ; Coll. Vol. 2: 29 .

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2-Aminoizobuterna kiselina

Reference[uredi | uredi kod]

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