N-acetilmuraminska kiselina 6-fosfatna eteraza
(Preusmjereno sa stranice EC 4.2.1.126)
| N-acetilmuraminska kiselina 6-fosfatna eteraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.126 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-acetilmuraminska kiselina 6-fosfatna eteraza (EC 4.2.1.126, MurNAc-6-P eteraza, MurQ) je enzim sa sistematskim imenom (R)-laktat hidrolijaza (dodaje N-acetil-D-glukozamin 6-fosfat, formira N-acetilmuramat 6-fosfat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-laktat + N-acetil-D-glukozamin 6-fosfat N-acetilmuramat 6-fosfat + H2O
Ovaj enzim, zajedno sa EC 2.7.1.170, anhidro-N-acetilmuraminsko kiselinskom kinazom, je neophodan da bi proteobakterije iskoristile anhidro-N-acetilmuraminsku kiselinu.
Reference[uredi | uredi kod]
- ↑ Jaeger, T., Arsic, M. and Mayer, C. (2005). „Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"”. J. Biol. Chem. 280: 30100-30106. PMID 15983044.
- ↑ Uehara, T., Suefuji, K., Valbuena, N., Meehan, B., Donegan, M. and Park, J.T. (2005). „Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate”. J. Bacteriol. 187: 3643-3649. PMID 15901686.
- ↑ Uehara, T., Suefuji, K., Jaeger, T., Mayer, C. and Park, J.T. (2006). „MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall”. J. Bacteriol. 188: 1660-1662. PMID 16452451.
- ↑ Hadi, T., Dahl, U., Mayer, C. and Tanner, M.E. (2008). „Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling”. Biochemistry 47: 11547-11558. PMID 18837509.
- ↑ Jaeger, T. and Mayer, C. (2008). „N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism”. Cell. Mol. Life Sci. 65: 928-939. PMID 18049859.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.