Sekoizolaricirezinol dehidrogenaza
(Preusmjereno sa stranice EC 1.1.1.331)
| Sekoizolaricirezinol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.331 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sekoizolaricirezinol dehidrogenaza (EC 1.1.1.331, sekoizolaricirezinolna dehidrogenaza) je enzim sa sistematskim imenom (-)-sekoizolaricirezinol:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (-)-sekoizolaricirezinol + 2 NAD+ (-)-matairezinol + 2 NADH + 2 H+
Ovaj enzim je izolovan iz biljki Forsythia intermedia i Podophyllum peltatum. In vitro se formira intermedijerni laktol.
Reference[uredi | uredi kod]
- ↑ Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). „Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection”. J. Biol. Chem. 276: 12614-12623. PMID 11278426.
- ↑ Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). „Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans”. J. Biol. Chem. 280: 12917-12926. PMID 15653677.
- ↑ Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). „Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum”. Org. Biomol. Chem. 4: 808-816. PMID 16493463.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.