Vitamin D3 24-hidroksilaza
(Preusmjereno sa stranice CYP24A1)
| Vitamin D3 24-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.126 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Vitamin D3 24-hidroksilaza (EC 1.14.13.126, CYP24A1) je enzim sa sistematskim imenom kalcitriol,NADPH:kiseonik oksidoreduktaza (24-hidroksilacija).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) kalcitriol + NADPH + H+ + O2 kalcitetrol + NADP+ +H2O
- (2) kalcidiol + NADPH + H+ + O2 sekalciferol + NADP+ +H2O
Ovaj enzim je hem-tiolatni enzim (P-450).
Reference[uredi | uredi kod]
- ↑ Masuda, S., Strugnell, S.A., Knutson, J.C., St-Arnaud, R. and Jones, G. (2006). „Evidence for the activation of 1α-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1α,24-dihydroxyvitamin D2 and 1α,25-dihydroxyvitamin D2”. Biochim. Biophys. Acta 1761: 221-234. PMID 16516540.
- ↑ Hamamoto, H., Kusudo, T., Urushino, N., Masuno, H., Yamamoto, K., Yamada, S., Kamakura, M., Ohta, M., Inouye, K. and Sakaki, T. (2006). „Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats”. Mol. Pharmacol. 70: 120-128. PMID 16617161.
- ↑ Sakaki, T., Kagawa, N., Yamamoto, K. and Inouye, K. (2005). „Metabolism of vitamin D3 by cytochromes P450”. Front. Biosci. 10: 119-134. PMID 15574355.
- ↑ Prosser, D.E., Kaufmann, M., O'Leary, B., Byford, V. and Jones, G. (2007). „Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH)2D3-26,23-lactone”. Proc. Natl. Acad. Sci. USA 104: 12673-12678. PMID 17646648.
- ↑ Kusudo, T., Sakaki, T., Abe, D., Fujishima, T., Kittaka, A., Takayama, H., Hatakeyama, S., Ohta, M. and Inouye, K. (2004). „Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24A1”. Biochem. Biophys. Res. Commun. 321: 774-782. PMID 15358094.
- ↑ Sawada, N., Kusudo, T., Sakaki, T., Hatakeyama, S., Hanada, M., Abe, D., Kamao, M., Okano, T., Ohta, M. and Inouye, K. (2004). „Novel metabolism of 1 α,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1”. Biochemistry 43: 4530-4537. PMID 15078099.
- ↑ Prosser, D.E. and Jones, G. (2004). „Enzymes involved in the activation and inactivation of vitamin D”. Trends Biochem. Sci. 29: 664-673. PMID 15544953.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.