Linalool 8-monooksigenaza
(Preusmjereno sa stranice CYP111)
| Linalool 8-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.151 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Linalool 8-monooksigenaza (EC 1.14.13.151, P-450lin, CYP111) je enzim sa sistematskim imenom linalol,NADH:kiseonik oksidoreduktaza (8-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- linalool + 2 NADH + 2 H+ + 2 O2 (6E)-8-oksolinalol + 2 NAD+ + 3H2O (sveukupna reakcija)
- (1a) linalol + NADH + H+ + O2 (6E)-8-hidroksilinalol + NAD+ + H2O
- (1b) (6E)-8-hidroksilinalol + NADH + H+ + O2 (6E)-8-oksolinalol + NAD+ + 2H2O
Ovaj enzim je hem-tiolatni protein (P-450). Sekundarni elektronski donor je specifično [2Fe-2S] feredoksin iz iste bakterijske vrste.
Reference[uredi | uredi kod]
- ↑ Ullah, A.J., Murray, R.I., Bhattacharyya, P.K., Wagner, G.C. and Gunsalus, I.C. (1990). „Protein components of a cytochrome P-450 linalool 8-methyl hydroxylase”. J. Biol. Chem. 265: 1345-1351. PMID 2295633.
- ↑ Ropp, J.D., Gunsalus, I.C. and Sligar, S.G. (1993). „Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita”. J. Bacteriol. 175: 6028-6037. PMID 8376348.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.