2-Dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisni)
(Preusmjereno sa stranice BtrN (gene name))
| 2-Dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisni) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.38 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisni) (EC 1.1.99.38, btrN (gen)) je enzim sa sistematskim imenom 2-dezoksi-scilo-inozamin:S-adenosyl-L-metionin 1-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-dezoksi-scilo-inozamin + S-adenozil-L-metionin 3-amino-2,3-didezoksi-scilo-inosoza + 5'-dezoksiadenozin + L-metionin
Ovaj enzim učestvuje u biosintezi aminoglikozidnih antibiotika iz butirozinske familije. Enzim iz Bacillus circulans koristi S-adenozil-L-metionin (SAM), cf. EC 1.1.1.329, 2-dezoksi-scilo-inozamin dehidrogenaza.
Reference[uredi | uredi kod]
- ↑ Yokoyama, K., Numakura, M., Kudo, F., Ohmori, D. and Eguchi, T. (2007). „Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin”. J. Am. Chem. Soc. 129: 15147-15155. PMID 18001019.
- ↑ Yokoyama, K., Ohmori, D., Kudo, F. and Eguchi, T. (2008). „Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy”. Biochemistry 47: 8950-8960. PMID 18672902.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.