(Butirosin acil-nosilac protein)—L-glutamat ligaza
(Preusmjereno sa stranice BtrJ)
| (Butirosin acil-nosilac protein)—L-glutamat ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.2.1.39 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(Butirosin acil-nosilac protein)—L-glutamat ligaza (EC 6.2.1.39, (BtrI acil-nosilac protein)—L-glutamat ligaza, BtrJ) je enzim sa sistematskim imenom (BtrI acil-nosilac protein):L-glutamat ligaza (formira ADP).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) ATP + L-glutamat + BtrI acil-nosilac protein ADP + fosfat + L-glutamil-[BtrI acil-nosilac protein]
- (2) ATP + L-glutamat + 4-amino butanoil-[BtrI acil-nosilac protein] ADP + fosfat + 4-(gama-L-glutamilamino)butanoil-[BtrI acil-nosilac protein]
Ovaj enzim katalizuje dva koraka u biosintezi bočnog lanca aminoglikozidnih antibiotika iz butirozinske familije.
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.