BIRC2

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Bakulovirni protein 2, koji sadrži IAP ponavljanje

PDB prikaz baziran na 1qbh.
Dostupne strukture
1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4
Identifikatori
SimboliBIRC2; API1; HIAP2; Hiap-2; MIHB; RNF48; c-IAP1; cIAP1
Vanjski IDOMIM601712 MGI1197009 HomoloGene900 GeneCards: BIRC2 Gene
Pregled RNK izražavanja
PBB GE BIRC2 202076 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez32911797
EnsemblENSG00000110330ENSMUSG00000057367
UniProtQ13490Q62210
RefSeq (mRNA)NM_001166.4NM_007465.2
RefSeq (protein)NP_001157.1NP_031491.2
Lokacija (UCSC)Chr 11:
102.22 - 102.25 Mb
Chr 9:
7.82 - 7.84 Mb
PubMed pretraga[1][2]

Bakuloviralni protein 2 koji sadrži IAP ponavljanje (cIAP1) je protein koji je kod ljudi kodiran BIRC2 genom.[1][2]

cIAP1 je član familije inhibitora apoptoze, koja inhibira apoptozu putem ometanja dejstva kaspaza.

Interakcije[uredi - уреди | uredi izvor]

BIRC2 formira interakcije sa HtrA serinskom peptidazom 2,[3][4] Diablo homologom,[3][5] TRAF1,[6][7][8] TRAF2,[6][7][8][9][10][11] HSP90B1,[12] RIPK1,[13] Kaspaza-9,[14] TNFSF14,[15] GSPT1,[3] RIPK2[16][17] i Ubikvitin C.[12][13][18]

Reference[uredi - уреди | uredi izvor]

  1. Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature 379 (6563): 349–53. PMID 8552191. doi:10.1038/379349a0. 
  2. Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell 83 (7): 1243–52. PMID 8548810. doi:10.1016/0092-8674(95)90149-3. 
  3. 3,0 3,1 3,2 Hegde, Ramesh; Srinivasula Srinivasa M, Datta Pinaki, Madesh Muniswamy, Wassell Richard, Zhang ZhiJia, Cheong NaEun, Nejmeh Julie, Fernandes-Alnemri Teresa, Hoshino Shin-ichi, Alnemri Emad S (October 2003). "The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein". J. Biol. Chem. (United States) 278 (40): 38699–706. ISSN 0021-9258. PMID 12865429. doi:10.1074/jbc.M303179200. 
  4. Verhagen, Anne M; Silke John, Ekert Paul G, Pakusch Miha, Kaufmann Hitto, Connolly Lisa M, Day Catherine L, Tikoo Anjali, Burke Richard, Wrobel Carolyn, Moritz Robert L, Simpson Richard J, Vaux David L (January 2002). "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins". J. Biol. Chem. (United States) 277 (1): 445–54. ISSN 0021-9258. PMID 11604410. doi:10.1074/jbc.M109891200. 
  5. Verhagen, A M; Ekert P G, Pakusch M, Silke J, Connolly L M, Reid G E, Moritz R L, Simpson R J, Vaux D L (July 2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell (United States) 102 (1): 43–53. ISSN 0092-8674. PMID 10929712. doi:10.1016/S0092-8674(00)00009-X. 
  6. 6,0 6,1 Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C (December 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. (ENGLAND) 16 (23): 6914–25. ISSN 0261-4189. PMC 1170295. PMID 9384571. doi:10.1093/emboj/16.23.6914. 
  7. 7,0 7,1 Shu, H B; Takeuchi M, Goeddel D V (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. (United States) 93 (24): 13973–8. ISSN 0027-8424. PMC 19479. PMID 8943045. doi:10.1073/pnas.93.24.13973. 
  8. 8,0 8,1 Li, Xiaoming; Yang Yili, Ashwell Jonathan D (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature (England) 416 (6878): 345–7. ISSN 0028-0836. PMID 11907583. doi:10.1038/416345a. 
  9. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  10. Uren, A G; Pakusch M, Hawkins C J, Puls K L, Vaux D L (May 1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. (United States) 93 (10): 4974–8. ISSN 0027-8424. PMC 39390. PMID 8643514. doi:10.1073/pnas.93.10.4974. 
  11. Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. (United States) 275 (15): 11114–20. ISSN 0021-9258. PMID 10753917. doi:10.1074/jbc.275.15.11114. 
  12. 12,0 12,1 Didelot, C; Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C (May 2008). "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation". Cell Death Differ. (England) 15 (5): 859–66. ISSN 1350-9047. PMID 18239673. doi:10.1038/cdd.2008.5. 
  13. 13,0 13,1 Bertrand, Mathieu J M; Milutinovic Snezana, Dickson Kathleen M, Ho Wai Chi, Boudreault Alain, Durkin Jon, Gillard John W, Jaquith James B, Morris Stephen J, Barker Philip A (June 2008). "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Mol. Cell (United States) 30 (6): 689–700. PMID 18570872. doi:10.1016/j.molcel.2008.05.014. 
  14. Deveraux, Q L; Roy N, Stennicke H R, Van Arsdale T, Zhou Q, Srinivasula S M, Alnemri E S, Salvesen G S, Reed J C (April 1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. (ENGLAND) 17 (8): 2215–23. ISSN 0261-4189. PMC 1170566. PMID 9545235. doi:10.1093/emboj/17.8.2215. 
  15. Kuai, June; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. (United States) 278 (16): 14363–9. ISSN 0021-9258. PMID 12571250. doi:10.1074/jbc.M208672200. 
  16. McCarthy, J V; Ni J, Dixit V M (July 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. (United States) 273 (27): 16968–75. ISSN 0021-9258. PMID 9642260. doi:10.1074/jbc.273.27.16968. 
  17. Thome, M; Hofmann K, Burns K, Martinon F, Bodmer J L, Mattmann C, Tschopp J (July 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr. Biol. (ENGLAND) 8 (15): 885–8. ISSN 0960-9822. PMID 9705938. doi:10.1016/S0960-9822(07)00352-1. 
  18. Sekine, Keiko; Takubo Kohei, Kikuchi Ryo, Nishimoto Michie, Kitagawa Masayuki, Abe Fuminori, Nishikawa Kiyohiro, Tsuruo Takashi, Naito Mikihiko (April 2008). "Small molecules destabilize cIAP1 by activating auto-ubiquitylation". J. Biol. Chem. (United States) 283 (14): 8961–8. ISSN 0021-9258. PMID 18230607. doi:10.1074/jbc.M709525200. 

Literatura[uredi - уреди | uredi izvor]