Aerobaktinska sintaza

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Aerobaktinska sintaza
Identifikatori
EC broj 6.3.2.39
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Aerobaktinska sintaza (EC 6.3.2.39, iucC (gen)) je enzim sa sistematskim imenom N2-citril-N6-acetil-N6-hidroksi-L-lizin:N6-acetil-N6-hidroksi-L-lizin ligaza (formira ADP).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 ATP + N2-citril-N6-acetil-N6-hidroksi-L-lizin + N6-acetil-N6-hidroksi-L-lizin + H2O 2 ADP + 2 fosfat + aerobaktin

Za dejstvo ovog enzima je neophodan jon Mg2+.

Reference[uredi - уреди | uredi izvor]

  1. Appanna, D.L., Grundy, B.J., Szczepan, E.W. and Viswanatha, T. (1984). "Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1". Biochim. Biophys. Acta 801: 437–443. 
  2. Gibson, F. and Magrath, D.I. (1969). "The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I". Biochim. Biophys. Acta 192: 175–184. PMID 4313071. 
  3. Maurer, P.J. and Miller, M. (1982). "Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine". J. Am. Chem. Soc. 104: 3096–3101. 
  4. de Lorenzo, V., Bindereif, A., Paw, B.H. and Neilands, J.B. (1986). "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". J. Bacteriol. 165: 570–578. PMID 2935523. 
  5. de Lorenzo, V. and Neilands, J.B. (1986). "Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli". J. Bacteriol. 167: 350–355. PMID 3087960. 
  6. Challis, G.L. (2005). "A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases". ChemBioChem 6: 601–611. PMID 15719346. 

Literatura[uredi - уреди | uredi izvor]

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