Acil-KoA dehidrogenaza veoma dugog lanca
(Preusmjereno sa stranice ACADVL (gene name).)
| Acil-KoA dehidrogenaza veoma dugog lanca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Dimer acil-KoA dehidrogenaze veoma dugog lanca (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acil-KoA dehidrogenaza veoma dugog lanca (EC 1.3.8.9, ACADVL (gen).) je enzim sa sistematskim imenom acil-KoA veoma dugog lanca:elektron-transfer flavoprotein 2,3-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA veoma dugog lanca + elektron-transfer flavoprotein trans-2,3-dehidroacil-KoA veoma dugog lanca + redukovani elektron-transfer flavoprotein
Ovaj enzim sadrži FAD kao prostetičku grupu. On je jedan od nekoliko enzima koji katalizuju prvi kora u beta oksidaciji masnih kiselina.
Reference[uredi | uredi kod]
- ↑ Izai, K., Uchida, Y., Orii, T., Yamamoto, S. and Hashimoto, T. (1992). „Novel fatty acid β-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase”. J. Biol. Chem. 267: 1027-1033. PMID 1730632.
- ↑ Aoyama, T., Souri, M., Ushikubo, S., Kamijo, T., Yamaguchi, S., Kelley, R.I., Rhead, W.J., Uetake, K., Tanaka, K. and Hashimoto, T. (1995). „Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients”. J. Clin. Invest. 95: 2465-2473. PMID 7769092.
- ↑ McAndrew, R.P., Wang, Y., Mohsen, A.W., He, M., Vockley, J. and Kim, J.J. (2008). „Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase”. J. Biol. Chem. 283: 9435-9443. PMID 18227065.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.