4-Hidroksifenilacetaldehid oksim monooksigenaza
(Preusmjereno sa stranice 4-hidroksifenilacetaldehid oksim monooksigenaza)
| 4-Hidroksifenilacetaldehid oksim monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.68 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4-Hidroksifenilacetaldehid oksim monooksigenaza (EC 1.14.13.68, 4-hidroksibenzenacetaldehid oksimska monooksigenaza, citohrom P450II-zavisna monooksigenaza, NADPH-citohrom P450 reduktaza (CYP71E1), CYP71E1, 4-hidroksifenilacetaldehid oksim,NADPH:kiseonik oksidoreduktaza) je enzim sa sistematskim imenom (Z)-4-hidroksifenilacetaldehid oksim,NADPH:kiseonik oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (Z)-4-hidroksifenilacetaldehid oksim + NADPH + H+ + O2 (S)-4-hidroksimandelonitril + NADP+ + 2H2O
Ovaj enzim učestvuju u biosintezi cijanogenig glukozida dhurina.
Reference[uredi | uredi kod]
- ↑ MacFarlane, I.J., Lees, E.M. and Conn, E.E. (1975). „The in vitro biosynthesis of dhurrin, the cyanogenic glycoside of Sorghum bicolor”. J. Biol. Chem. 250: 4708-4713. PMID 237909.
- ↑ Shimada, M. and Conn, E.E. (1977). „The enzymatic conversion of p-hydroxyphenylacetaldoxime to p-hydroxymandelonitrile”. Arch. Biochem. Biophys. 180: 199-207. PMID 193443.
- ↑ Busk, P.K. and Møller, B.L. (2002). „Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants”. Plant Physiol. 129: 1222-1231. PMID 12114576.
- ↑ Kristensen, C., Morant, M., Olsen, C.E., Ekstrøm, C.T., Galbraith, D.W., Møller, B.L. and Bak, S. (2005). „Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome”. Proc. Natl. Acad. Sci. USA 102: 1779-1784. PMID 15665094.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.