3-Okso-5,6-dehidrosuberil-KoA semialdehid dehidrogenaza
(Preusmjereno sa stranice 3-okso-5,6-dehidrosuberil-KoA semialdehid dehidrogenaza)
| 3-Okso-5,6-dehidrosuberil-KoA semialdehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.1.7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3-Okso-5,6-dehidrosuberil-KoA semialdehid dehidrogenaza (EC 1.17.1.7, paaZ (gen)) je enzim sa sistematskim imenom 3-okso-5,6-dehidrosuberil-KoA semialdehid:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-okso-5,6-dehidrosuberil-KoA semialdehid + NADP+ + H2O 3-okso-5,6-dehidrosuberil-KoA + NADPH + H+
Enzim iz Escherichia coli je bifunkcionalni protein koji takođe katalizuje reakciju enzima EC 3.7.1.16, oksepin-KoA hidrolaze.
Reference[uredi | uredi kod]
- ↑ Ferrandez, A., Minambres, B., Garcia, B., Olivera, E.R., Luengo, J.M., Garcia, J.L. and Diaz, E. (1998). „Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway”. J. Biol. Chem. 273: 25974-25986. PMID 9748275.
- ↑ Ismail, W., El-Said Mohamed, M., Wanner, B.L., Datsenko, K.A., Eisenreich, W., Rohdich, F., Bacher, A. and Fuchs, G. (2003). „Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli”. Eur. J. Biochem. 270: 3047-3054. PMID 12846838.
- ↑ Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. (2010). „Bacterial phenylalanine and phenylacetate catabolic pathway revealed”. Proc. Natl. Acad. Sci. USA 107: 14390-14395. PMID 20660314.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.