(-)-Alfa-pinenska sintaza
(Preusmjereno sa stranice (-)-alfa-pinen sintaza)
| (-)-Alfa-pinenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.119 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(-)-Alfa-pinenska sintaza (EC 4.2.3.119, (-)-alfa-pinen/(-)-kamken sintaza, (-)-alfa-pinen ciklaza) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira (-)-alfa-pinen).[1][2][3][4][5][6][7][8][9][10][11][12][13][14] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat (-)-alfa-pinen + difosfat
Ciklaza II iz Salvia officinalis formira jednake količine (-)-alfa-pinena, (-)-beta-pinena i (-)-kamfena.
- ↑ Gambliel, H. and Croteau, R. (1984). „Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration”. J. Biol. Chem. 259: 740-748. PMID 6693393.
- ↑ Croteau, R.B., Wheeler, C.J., Cane, D.E., Ebert, R. and Ha, H.J. (1987). „Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-)-α-pinene and (-)-β-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate”. Biochemistry 26: 5383-5389. PMID 3314988.
- ↑ Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1988). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene”. J. Biol. Chem. 263: 10063-10071. PMID 3392006.
- ↑ Croteau, R. and Satterwhite, D.M. (1989). „Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage”. J. Biol. Chem. 264: 15309-15315. PMID 2768265.
- ↑ Pyun, H.J., Wagschal, K.C., Jung, D.I., Coates, R.M. and Croteau, R. (1994). „Stereochemistry of the proton elimination in the formation of (+)- and (-)-α-pinene by monoterpene cyclases from sage (Salvia officinalis)”. Arch. Biochem. Biophys. 308: 488-496. PMID 8109979.
- ↑ Lu, S., Xu, R., Jia, J.W., Pang, J., Matsuda, S.P. and Chen, X.Y. (2002). „Cloning and functional characterization of a β-pinene synthase from Artemisia annua that shows a circadian pattern of expression”. Plant Physiol. 130: 477-486. PMID 12226526.
- ↑ Lewinsohn, E., Gijzen, M. and Croteau, R. (1992). „Wound-inducible pinene cyclase from grand fir: purification, characterization, and renaturation after SDS-PAGE”. Arch. Biochem. Biophys. 293: 167-173. PMID 1731633.
- ↑ Bohlmann, J., Steele, C.L. and Croteau, R. (1997). „Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase”. J. Biol. Chem. 272: 21784-21792. PMID 9268308.
- ↑ Bohlmann, J., Phillips, M., Ramachandiran, V., Katoh, S. and Croteau, R. (1999). „cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis)”. Arch. Biochem. Biophys. 368: 232-243. PMID 10441373.
- ↑ Hyatt, D.C. and Croteau, R. (2005). „Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis”. Arch. Biochem. Biophys. 439: 222-233. PMID 15978541.
- ↑ Phillips, M.A., Savage, T.J. and Croteau, R. (1999). „Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers”. Arch. Biochem. Biophys. 372: 197-204. PMID 10562434.
- ↑ Phillips, M.A., Wildung, M.R., Williams, D.C., Hyatt, D.C. and Croteau, R. (2003). „cDNA isolation, functional expression, and characterization of (+)-α-pinene synthase and (-)-α-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis”. Arch. Biochem. Biophys. 411: 267-276. PMID 12623076.
- ↑ McKay, S.A., Hunter, W.L., Godard, K.A., Wang, S.X., Martin, D.M., Bohlmann, J. and Plant, A.L. (2003). „Insect attack and wounding induce traumatic resin duct development and gene expression of (-)-pinene synthase in Sitka spruce”. Plant Physiol. 133: 368-378. PMID 12970502.
- ↑ Huber, D.P.W., Philippe, R.N., Godard, K.-A., Sturrock, R.N. and Bohlmann, J. (2005). „Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii”. Phytochemistry 66: 1427-1439. PMID 15921711.
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