(+)-Kar-3-enska sintaza
Izgled
(Preusmjereno sa stranice (+)-kar-3-enska sintaza)
(+)-Kar-3-enska sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.2.3.107 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(+)-Kar-3-enska sintaza (EC 4.2.3.107, 3-karenska ciklaza, 3-karenska sintaza, 3CAR, (+)-3-karenska sintaza) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira (+)-car-3-en).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat (+)-kar-3-en + difosfat
Ovaj enzim reaguje sa (3S)-linalil difosfatom dva puta brže od geranil difosfata.
- ↑ Savage, T.J. and Croteau, R. (1993). „Biosynthesis of monoterpenes: regio- and stereochemistry of (+)-3-carene biosynthesis”. Arch. Biochem. Biophys. 305: 581-587. PMID 8373196.
- ↑ Savage, T.J., Ichii, H., Hume, S.D., Little, D.B. and Croteau, R. (1995). „Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents”. Arch. Biochem. Biophys. 320: 257-265. PMID 7625832.
- ↑ Savage, T.J., Hatch, M.W. and Croteau, R. (1994). „Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase”. J. Biol. Chem. 269: 4012-4020. PMID 8307957.
- ↑ Faldt, J., Martin, D., Miller, B., Rawat, S. and Bohlmann, J. (2003). „Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase”. Plant Mol. Biol. 51: 119-133. PMID 12602896.
- ↑ Hamberger, B., Hall, D., Yuen, M., Oddy, C., Hamberger, B., Keeling, C.I., Ritland, C., Ritland, K. and Bohlmann, J. (2009). „Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca) BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into a conifer genome”. BMC Plant Biol. 9: #106-106. PMID 19656416.
- ↑ Hall, D.E., Robert, J.A., Keeling, C.I., Domanski, D., Quesada, A.L., Jancsik, S., Kuzyk, M.A., Hamberger, B., Borchers, C.H. and Bohlmann, J. (2011). „An integrated genomic, proteomic and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil”. Plant J. 65: 936-948. PMID 21323772.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.