Lezogaberan

Izvor: Wikipedia
Lezogaberan
Lesogaberan.svg
IUPAC ime
Drugi nazivi AZD-3355
Identifikacija
CAS registarski broj 344413-67-8 YesY
PubChem[1][2] 9833984
UNII 4D6Q6HGC7Z YesY
ChEMBL[3] CHEMBL448343
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C3H9FNO2P
Molarna masa 141.08 g mol−1

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Lezogaberan (AZD-3355) je[4] eksperimentalni lek za tretiranje gastroesofagealna refluksne bolesti.[5] On je agonist GABAB receptora,[6] i ima isti mehanizam dejstva kao i baklofen, ali se očekuje da će imati manje nuspojava vezanih za centralni nervni sistem, koje ograničavaju kliničku primenu baklofena.[7]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  4. AstraZeneca. "AZD3355". http://www.astrazenecaclinicaltrials.com/other-drug-products/discontinued-products/AZD3355/. pristupljeno 30. 12. 2011.. 
  5. Bredenoord, Albert J. (2009). "Lesogaberan, a GABAB agonist for the potential treatment of gastroesophageal reflux disease". IDrugs 12 (9): 576–584. PMID 19697277. 
  6. Alstermark, et al.; Amin, K; Dinn, SR; Elebring, T; Fjellström, O; Fitzpatrick, K; Geiss, WB; Gottfries, J et al. (2008). "Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors". Journal of Medicinal Chemistry 51 (14): 4315–4320. doi:10.1021/jm701425k. PMID 18578471. 
  7. Brian E. Lacy, Robert Chehade, and Michael D. Crowell (2010). "Lesogaberan". Drugs of the Future 35 (12): 987–992. doi:10.1358/dof.2010.035.012.1540661. 

Spoljašnje veze[uredi - уреди]