Izvorni kod stranice Karmustin

{{Chembox-lat
| Verifiedfields = 
| Watchedfields = 
| verifiedrevid = 487305398
| ImageFile = Carmustine.svg
| ImageFile_Ref = {{chemboximage|correct|}}
| ImageName = Skeletal formula of carmustine
| ImageFile1 = Carmustine ball-and-stick.png
| ImageName1 = Ball-and-stick model of carmustine molecule
| IUPACName = 1,3-Bis(2-hloroetil)-1-nitrozoureja<ref>{{cite web|title=Carmustine - Compound Summary|url=http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2578#x291|work=PubChem Compound|publisher=National Center for Biotechnology Information|accessdate = 11. 4. 2012.|location=USA|date = 25. 3. 2005.|at=Identification}}</ref>
| OtherNames = ''N'',''N''’-Bis(2-hloroetil)-''N''-nitrozo-ureja
| Section1 = {{Chembox Identifiers-lat
|  CASNo = 154-93-8
|  CASNo_Ref = {{cascite|correct|CAS}}
|  PubChem = 2578
|  PubChem_Ref = {{pubchemcite|correct|pubchem}}
|  ChemSpiderID = 2480
|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
|  UNII = U68WG3173Y
|  UNII_Ref = {{fdacite|correct|FDA}}
|  EINECS = 205-838-2
|  UNNumber = 2811
|  DrugBank = DB00262
|  DrugBank_Ref = {{drugbankcite|correct|drugbank}}
|  KEGG = D00254
|  KEGG_Ref = {{keggcite|correct|kegg}}
|  MeSHName = Carmustine
|  ChEBI = 3423
|  ChEBI_Ref = {{ebicite|correct|EBI}}
|  ChEMBL = 513
|  ChEMBL_Ref = {{ebicite|correct|EBI}}
|  RTECS = YS2625000
|  ATCCode_prefix = L01
|  ATCCode_suffix = AD01
|  SMILES1 = ClCCNC(=O)N(CCCl)N=O
|  StdInChI = 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
|  StdInChI_Ref = {{stdinchicite|correct|chemspider}}
|  StdInChIKey = DLGOEMSEDOSKAD-UHFFFAOYSA-N
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  Beilstein = 
|  Gmelin = 
|  3DMet = 
}}
| Section2 = {{chembox Properties-lat
|  C = 5
|  H = 9
|  Cl = 2
|  N = 3
|  O = 2
|  Appearance = Orange crystals-lat
|  Odor = Bez mirisa
|  MeltingPtC = 30
|  LogP = 1,375
|  pKa = 10,194
|  pKb = 3,803
}}
| Section3 = {{Chembox Pharmacology-lat
|  Bioavail = 5–28%
|  AdminRoutes = Intravenozno
|  Metabolism = Hepatički
|  HalfLife = 15–30 min
|  ProteinBound = 80%
|  Excretion = {{unbulleted list|Renalno|Respiratorno}}
|  Legal_status = Rx
|  PregCat_US = D
}}
| Section4 = {{Chembox Hazards-lat
|  GHSPictograms = 
|  GHSSignalWord = '''Opsasnost'''
|  HPhrases = {{h-phrases|300|350|360}}
|  PPhrases = {{p-phrases|301+310|308+313}}
|  EUClass = {{hazchem T+}}
|  RPhrases = {{r45}}, {{r46}}, {{r60}}, {{r61}}, {{r28}}
|  SPhrases = {{s22}}, {{s36/37/39}}, {{s45}}
|  LD50 = 20 mg kg<sup>−1</sup> <small>(oralno, pacov)</small>
}}
| Section5 = {{Chembox Related-lat
|  Function = ureje
|  OtherFunctn = [[Dimetilureja]]
|  OtherCpds = {{unbulleted list|[[Noksitiolin]]|[[1,1,3,3-Tetrametilguanidin]]|[[Metformin]]|[[Alantoinska kiselina]]|[[Buformin]]}}
}}
}}

'''Karmustin''' ili ''BCNU'' (bis-hloroetilnitrozoureja) je β-hloro-[[Nitrozoureja|nitrozourejno]] jedinjenje strodno sa [[azotni iperit|azotnim iperitom]], koje se koristi kao [[Alkilirajući antineoplastični agens|alkilirajući agens]] u [[hemoterapija|hemoterapiji]].<ref>{{cite journal |title = DrugBank 3.0: a comprehensive resource for omics research on drugs |author = Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS |journal = Nucleic Acids Res. |year = 2011 |volume = 39 |issue = Database issue |pages = D1035-41 | pmid =21059682}}</ref><ref>{{cite journal |title = DrugBank: a knowledgebase for drugs, drug actions and drug targets |author = Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M |journal = Nucleic Acids Res |year = 2008 |volume = 36 |issue = Database issue |pages = D901-6 |pmid = 18048412}}</ref> Kao dialkilirajući agens, BCNU ima sposobnost formiranja veza između DNK lanaca, čime se onemogućava [[Replikacija DNK|DNK replikacija]] i [[Transkripcija (genetika)|DNK transkripcija]].

It has the appearance of an orange-yellow solid.

Carmustine for injection is marketed under the name '''BiCNU''' by Bristol-Myers Squibb. In India, carmustine is marketed under the name '''Carustine''' by Curacell Biotech.

== Reference ==
{{reflist|2}}

== Spoljašnje veze ==
{{Portal-lat|Hemija}}
* {{MedlinePlusDrugInfo|medmaster|a682060}}
* [http://www.bms.com/cgi-bin/anybin.pl?sql=select%20PPI%20from%20TB_PRODUCT_PPI%20where%20PPI_SEQ=65&key=PPI BiCNU] {{Webarchive|url=https://web.archive.org/web/20070927200641/http://www.bms.com/cgi-bin/anybin.pl?sql=select%20PPI%20from%20TB_PRODUCT_PPI%20where%20PPI_SEQ=65&key=PPI |date=2007-09-27 }} (package insert; U.S.)

{{Intracelularni hemoterapijski agensi}}

[[Kategorija:Orfan lekovi]]
[[Kategorija:Ureje]]
[[Kategorija:Nitrozo jedinjenja]]
[[Kategorija:Alkilirajući antineoplastični agensi]]
[[Kategorija:Organohloridi]]