GNAT3
| edit |
| Vezujući protein guaninskog nukleotida, alfa jedinica 3 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | GNAT3; GDCA | ||
| Vanjski ID | OMIM: 139395 MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3 Gene | ||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 346562 | 242851 | |
| Ensembl | ENSG00000214415 | ENSMUSG00000028777 | |
| UniProt | A8MTJ3 | Q3V3I2 | |
| RefSeq (mRNA) | NM_001102386.1 | NM_001081143.1 | |
| RefSeq (protein) | NP_001095856.1 | NP_001074612.1 | |
| Lokacija (UCSC) | Chr 7: 80.09 - 80.14 Mb | Chr 5: 17.47 - 17.53 Mb | |
| PubMed pretraga | [1] | [2] | |
Vezujući protein guaninskog nukleotida G(t), alfa jedinica 3 (gustducin alfa-3 lanac) je protein koji je kod ljudi kodiran GNAT3 genom.[1]
Gustducin alfa-3 lanac je podjedinica heterotrimerinog proteina gustducina koji je odgovoran za osnovne ukuse.
- Oldham WM, Van Eps N, Preininger AM, et al. (2006). „Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.”. Nat. Struct. Mol. Biol. 13 (9): 772–7. DOI:10.1038/nsmb1129. PMID 16892066.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Rozengurt N, Wu SV, Chen MC, et al. (2006). „Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.”. Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792-802. DOI:10.1152/ajpgi.00074.2006. PMID 16728727.
- Huang L, Shanker YG, Dubauskaite J, et al. (1999). „Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.”. Nat. Neurosci. 2 (12): 1055–62. DOI:10.1038/15981. PMID 10570481.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Luttrell LM (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol. 39 (3): 239–64. DOI:10.1007/s12033-008-9031-1. PMID 18240029.
- Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). „T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. DOI:10.1073/pnas.0706678104. PMID 17724332.
- Takami S, Getchell TV, McLaughlin SK, et al. (1994). „Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.”. Brain Res. Mol. Brain Res. 22 (1-4): 193–203. DOI:10.1016/0169-328X(94)90047-7. PMID 8015379.
- Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). „Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode 2007PNAS..10415069J. DOI:10.1073/pnas.0706890104. PMID 17724330.
- Li X, Staszewski L, Xu H, et al. (2002). „Human receptors for sweet and umami taste.”. Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. DOI:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
- Fehr J, Meyer D, Widmayer P, et al. (2007). „Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.”. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 193 (1): 21–34. DOI:10.1007/s00359-006-0168-8. PMID 17021831.
- Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). „Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.”. Nature 369 (6482): 621–8. DOI:10.1038/369621a0. PMID 8208289.