Urat oksidaza

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Urat oksidaza
Identifikatori
EC broj 1.7.3.3
CAS broj 2594291
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Urat oksidaza (EC 1.7.3.3, urinsko kiselinska oksidaza, urikaza, urikaza II, uratna-oksidaza) je enzim sa sistematskim imenom urat:kiseonik oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

urat + O2 +H2O \rightleftharpoons 5-hidroksiizourat +H2O2

Enzimu iz zrna soje, plesni Aspergillus flavus i Bacillus subtilis ne sadrže bakar, niti druge jone prelaznih metala.

Reference[uredi - уреди]

  1. London, M. and Hudson, P.B. (1956). "Purification and properties of solubilized uricase". Biochim. Biophys. Acta 21: 290–298. PMID 13363909. 
  2. Mahler, H.R., Hübscher, G. and Baum, H. (1955). "Studies on uricase. I. Preparation, purification, and properties of a cuproprotein". J. Biol. Chem. 216: 625–641. PMID 13271340. 
  3. Robbins, K.C., Barnett, E.L. and Grant, N.H. (1955). "Partial purification of porcine liver uricase". J. Biol. Chem. 216: 27–35. PMID 13252004. 
  4. Kahn, K. and Tipton, P.A. (1998). "Spectroscopic characterization of intermediates in the urate oxidase reaction". Biochemistry 37: 11651–11659. PMID 9709003. 
  5. Colloc'h, N., el Hajji, M., Bachet, B., L'Hermite, G., Schiltz, M., Prange, T., Castro, B. and Mornon, J.-P. (1997). "Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution". Nat. Struct. Biol. 4: 947–952. PMID 9360612. 
  6. Imhoff, R.D., Power, N.P., Borrok, M.J. and Tipton, P.A. (2003). "General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad". Biochemistry 42: 4094–4100. PMID 12680763. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]