Signalna peptidaza II
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| Signalna peptidaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.36 | ||||||||
| CAS broj | 171715-14-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Signalna peptidaza II (EC 3.4.23.36, premurein-vodeća peptidaza, prolipoprotein signalna peptidaza, vodeća peptidaza II, premureinska vodeća proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje signalnih peptida sa bakterijskih membranskih prolipoproteina uključujući mureinski prolipoprotein. Hidroliza -Xaa-Yaa-Zaa-(S,diacilgliceril)Cys-, pri čemu je Xaa hidrofoban (preferentno Leu), i Yaa (Ala ili Ser) i Zaa (Gly ili Ala) imaju male, neutralne bočne lance
Ovaj enzim je prisutan na bakterijskim unutrašnjim membranama.
Reference[uredi | uredi kod]
- ↑ Dev, I.K. and Ray, P.H. (1990). „Signal peptidases and signal peptide hydrolases”. J. Bioenerg. Biomembr. 22: 271-290. PMID 2202720.
- ↑ Zhao, X.-J. and Wu, H.C. (1992). „Nucleotide sequence of the Staphylococcus aureus' signal peptidase II (lsp) gene”. FEBS Lett. 299: 80-84. PMID 1544479.
- ↑ Sankaran, K. and Wu, H.C. (1995). „Bacterial prolipoprotein signal peptidase”. Methods Enzymol. 248: 169-180. PMID 7674920.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.