Serinska racemaza
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| Serinska racemaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 5.1.1.18 | ||||||||
| CAS broj | 77114-08-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Serinska racemaza (EC 5.1.1.18, SRR) je enzim sa sistematskim imenom serin racemaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-serin D-serin
Ovaj enzim sadrži piridoksal fosfat.
Reference[uredi | uredi kod]
- ↑ Wolosker, H., Blackshaw, S. and Snyder, S.H. (1999). „Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission”. Proc. Natl. Acad. Sci. USA 96: 13409-13414. PMID 10557334.
- ↑ Wolosker, H., Sheth, K.N., Takahashi, M., Mothet, J.P., Brady, R.O., Jr., Ferris, C.D. and Snyder, S.H. (1999). „Purification of serine racemase: biosynthesis of the neuromodulator D-serine”. Proc. Natl. Acad. Sci. USA 96: 721-725. PMID 9892700.
- ↑ De Miranda, J., Santoro, A., Engelender, S. and Wolosker, H. (2000). „Human serine racemase: moleular cloning, genomic organization and functional analysis”. Gene 256: 183-188. PMID 11054547.
- ↑ Foltyn, V.N., Bendikov, I., De Miranda, J., Panizzutti, R., Dumin, E., Shleper, M., Li, P., Toney, M.D., Kartvelishvily, E. and Wolosker, H. (2005). „Serine racemase modulates intracellular D-serine levels through an α,β-elimination activity”. J. Biol. Chem. 280: 1754-1763. PMID 15536068.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.