Polineuridin-aldehidna estaraza
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| Polineuridin-aldehidna estaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.78 | ||||||||
| CAS broj | 87041-55-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Polineuridin-aldehidna estaraza (EC 3.1.1.78, polineuridin aldehidna esteraza, PNAE) je enzim sa sistematskim imenom polineuridin aldehid hidrolaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- polineuridin aldehid + H2O 16-epivelozimin + CO2 + metanol
Nakon hidrolize ovog indolnog alkaloidnog estra, karboksilna kiselina se spontano dekarboksiliše dajući sarpaganski skeleton.
Reference[uredi | uredi kod]
- ↑ Pfitzner, A. and Stöckigt, J. (1983). „Characterization of polyneuridine aldehyde esterase, a key enzyme in the biosynthesis of sarpagine ajmaline type alkaloids”. Planta Med. 48: 221-227.
- ↑ Pfitzner, A. and Stöckigt, J. (1983). „Polyneuridine aldehyde esterase: an unusual specific enzyme involved in the biosynthesis of sarpagine type alkaloids”. J. Chem. Soc. Chem. Commun.: 459-460.
- ↑ Dogru, E., Warzecha, H., Seibel, F., Haebel, S., Lottspeich, F. and Stöckigt, J. (2000). „The gene encoding polyneuridine aldehyde esterase of monoterpenoid indole alkaloid biosynthesis in plants is an ortholog of the hydrolase super family”. Eur. J. Biochem. 267: 1397-1406. PMID 10691977.
- ↑ Mattern-Dogru, E., Ma, X., Hartmann, J., Decker, H. and Stöckigt, J. (2002). „Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis”. Eur. J. Biochem. 269: 2889-2896. PMID 12071952.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.