Pimelil-(acil-nosilac protein) metil estarska esteraza
Prijeđi na navigaciju
Prijeđi na pretragu
| Pimelil-(acil-nosilac protein) metil estarska esteraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.85 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pimelil-(acil-nosilac protein) metil estarska esteraza (EC 3.1.1.85, BioH) je enzim sa sistematskim imenom pimelil-(acil-nosilac protein) metil estar hidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- pimelil-[acil-nosilac protein] metil estar + H2O pimelil-[acil-nosilac protein] + metanol
Ovaj enzim učestvuje u biosintezi biotina u Gram-negativim bakterijama.
Reference[uredi | uredi kod]
- ↑ Sanishvili, R., Yakunin, A.F., Laskowski, R.A., Skarina, T., Evdokimova, E., Doherty-Kirby, A., Lajoie, G.A., Thornton, J.M., Arrowsmith, C.H., Savchenko, A., Joachimiak, A. and Edwards, A.M. (2003). „Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli”. J. Biol. Chem. 278: 26039-26045. PMID 12732651.
- ↑ Lemoine, Y., Wach, A. and Jeltsch, J.M. (1996). „To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli”. Mol. Microbiol. 19: 645-647. PMID 8830257.
- ↑ Tomczyk, N.H., Nettleship, J.E., Baxter, R.L., Crichton, H.J., Webster, S.P. and Campopiano, D.J. (2002). „Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway”. FEBS Lett. 513: 299-304. PMID 11904168.
- ↑ Lin, S., Hanson, R.E. and Cronan, J.E. (2010). „Biotin synthesis begins by hijacking the fatty acid synthetic pathway”. Nat. Chem. Biol.: -. PMID 20693992.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.