Peptidilglicin monooksigenaza

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Peptidilglicin monooksigenaza
Identifikatori
EC broj 1.14.17.3
CAS broj 90597-47-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Peptidilglicin monooksigenaza (EC 1.14.17.3, peptidilglicinska 2-hidroksilaza, peptidil alfa-amidirajući enzim, peptid-alfa-amidna sintetaza, sintaza, peptid alfa-amid, peptidni alfa-amidirajući enzim, peptidna alfa-amidna sintaza, peptidilglicinska alfa-hidroksilaza, peptidilglicinska alfa-amidirajuća monooksigenaza, PAM-A, PAM-B, PAM) je enzim sa sistematskim imenom peptidilglicin,askorbat:kiseonik oksidoreduktaza (2-hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidilglicin + askorbat + O2 \rightleftharpoons peptidil(2-hidroksiglicin) + dehidroaskorbat + H2O

Ovaj enzim sadrži bakar. Peptidilglicini sa neutralnim aminokiselinskim ostatkom u pretposlednjoj poziciji su najbolji supstrati.

Reference[uredi - уреди]

  1. Bradbury, A.F., Finnie, M.D.A. and Smyth, D.G. (1982). "Mechanism of C-terminal amide formation by pituitary enzymes". Nature (Lond.) 298: 686–688. PMID 7099265. 
  2. Bradbury, A.F. and Smyth, D.G. (1987). "Enzyme-catalysed peptide amidation. Isolation of a stable intermediate formed by reaction of the amidating enzyme with an imino acid". Eur. J. Biochem. 169: 579–584. PMID 3691506. 
  3. Glembotski, C.G. (1985). "Further characterization of the peptidyl α-amidating enzyme in rat anterior pituitary secretory granules". Arch. Biochem. Biophys. 241: 673–683. PMID 2994573. 
  4. Katopodis, A.G., Ping, D. and May, S.W. (1990). "A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of α-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine α-amidating monooxygenase in peptide amidation". Biochemistry 29: 6115–6120. PMID 2207061. 
  5. Murthy, A.S.N., Keutmann, H.T. and Eipper, B.A. (1987). "Further characterization of peptidylglycine α-amidating monooxygenase from bovine neurointermediate pituitary". Mol. Endocrinol. 1: 290–299. PMID 3453894. 
  6. Murthy, A.S.N., Mains, R.E. and Eipper, B.A. (1986). "Purification and characterization of peptidylglycine α-amidating monooxygenase from bovine neurointermediate pituitary". J. Biol. Chem. 261: 1815–1822. PMID 3944110. 

Literatura[uredi - уреди]

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