Otvarač kalijumskog kanala
Prijeđi na navigaciju
Prijeđi na pretragu
Otvarač kalijum kanala je tip leka koji posreduje jonsku transmisiju kroz kalijumske kanale.
Primeri lekova iz ove grupe su:
- Diazoksid[1] vazodilatator koji se koristi za tretman hipertenzije, i relaksaciju glatkih mišića
- Minoksidil[2] vazodilator koji se koristi za hipertenziju, kao i za sprečavanje gubitka kose
- Nikorandil[3] vazodilator koji se koristi za tretman angine
- Pinacidil[4]
- Retigabin,[5][6] antikonvulsant
- Flupirtin, analgetik sa svojstvima mišićnog relaksanta i antikonvulsanta
Reference[uredi | uredi kod]
- ↑ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). „Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener”. Circulation 112 (9 Suppl): I219–23. DOI:10.1161/CIRCULATIONAHA.104.523746. PMID 16159820.
- ↑ Wang T (February 2003). „The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle”. J. Pharmacol. Exp. Ther. 304 (2): 833–40. DOI:10.1124/jpet.102.043380. PMID 12538840.
- ↑ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). „Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction”. Biol. Pharm. Bull. 31 (11): 2079–82. DOI:10.1248/bpb.31.2079. PMID 18981577.
- ↑ Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007). „Potassium channel opener pinacidil induces relaxation of the isolated human radial artery”. J. Pharmacol. Sci. 104 (2): 122–9. DOI:10.1254/jphs.FP0061434. PMID 17538231.
- ↑ Rundfeldt C (October 1997). „The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells”. European Journal of Pharmacology 336 (2–3): 243–9. DOI:10.1016/S0014-2999(97)01249-1. PMID 9384239.
- ↑ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). „Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine”. Molecular Pharmacology 58 (2): 253–62. PMID 10908292. Arhivirano iz originala na datum 2019-12-09. Pristupljeno 2014-07-04.