Oktafluoropropan

Izvor: Wikipedia
Oktafluoropropan
Octafluoropropane.png
Identifikacija
CAS registarski broj 76-19-7 YesY
PubChem[1][2] 6432
ChemSpider[3] 6192 YesY
DrugBank DB00556
ChEBI 31980
ChEMBL[4] CHEMBL1663 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C3F8
Molarna masa 188.02 g mol−1
Tačka topljenja

-147.6

Tačka ključanja

-36.6

Farmakologija
Načini upotrebe Intravenozno
Vreme polu-uklanjanja iz organizma 1,9 minuta

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Oktafluoropropan je organsko jedinjenje, koje sadrži 3 atoma ugljenika i ima molekulsku masu od 188,019 Da.[5][6][7]

Osobine[uredi - уреди]

Osobina Vrednost
Broj akceptora vodonika 0
Broj donora vodonika 0
Broj rotacionih veza 2
Particioni koeficijent[8] (ALogP) 2,7
Rastvorljivost[9] (logS, log(mol/L)) -4,7
Polarna površina[10] (PSA, Å2) 0,0

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Quinones A, Benenstein R, Saric M: New-Onset Seizure after Perflutren Microbubble Injection during Dobutamine Stress Echocardiography. Echocardiography. 2013 Feb 22. doi: 10.1111/echo.12149. PMID 23432576
  6. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.  edit
  7. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901–6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.  edit
  8. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods". J. Phys. Chem. A 102: 3762–3772. doi:10.1021/jp980230o. 
  9. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488–1493. doi:10.1021/ci000392t. PMID 11749573.  edit
  10. Ertl P., Rohde B., Selzer P. (2000). "Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties". J. Med. Chem. 43: 3714–3717. doi:10.1021/jm000942e. PMID 11020286.  edit

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]