Mukorpepsin
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| Mukorpepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.23 | ||||||||
| CAS broj | 148465-73-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mukorpepsin (EC 3.4.23.23, Mucor renin, Mucor aspartinska proteinaza, Mucor kiselinska proteinaza, Mucor kiselinska proteaza, Mucor miehei aspartinsk proteinaza, Mucor miehei aspartinska proteaza, Mucor aspartinska proteinaza, Mucor pusillus emporaza, Fromase 100, Mucor pusillus renin, Fromase 46TL, Mucor miehei renin) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina, sa preferencijom za hidrofobne ostatke u P1 i P1'. Dolazi do zgrušavanja mleka. Ne dolazi do reakcije sa Lys u P1, i stoga ne dolazi do aktivacije tripsinogena
Ovaj enzim je prisutan u gljivama Mucor pusillus i M. miehei.
Reference[uredi | uredi kod]
- ↑ Arima, K., Yu, J. and Iwasaki, S. (1970). „Milk-clotting enzyme from Mucor pusillus var. lindt”. Methods Enzymol. 19: 446-459.
- ↑ Ottesen, M. and Rickert, W. (1970). „The acid protease of Mucor miehei”. Methods Enzymol. 19: 459-460.
- ↑ Sternberg, M. (1972). „Bond specificity, active site and milk cloting mechanism of the Mucor miehei protease”. Biochim. Biophys. Acta 285: 383-392. PMID 4573298.
- ↑ Oka, T., Ishino, K., Tsuzuki, H., Morihara, K. and Arima, K. (1973). „On the specificity of a rennin-like enzyme from Mucor pusillus”. Agric. Biol. Chem. 37: 1177-1184.
- ↑ Baudy, M., Foundling, S., Pavlik, M., Blundell, T. and Kostka, V. (1988). „Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment”. FEBS Lett. 235: 271-274. PMID 3042459.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.