Kjuin tRNK-riboziltransferaza

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Kjuin tRNK-riboziltransferaza
Identifikatori
EC broj 2.4.2.29
CAS broj 72162-89-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kjuin tRNK-riboziltransferaza (EC 2.4.2.29, enzim umetanja kjuina, tRNK transglikozilaza, Q-insertaza, kjuin34 transfer ribonukleatna riboziltransferaza, transfer ribonukleatna glikoziltransferaza, tRNK kjuin34 transglikosidaza, kjuinska tRNK-riboziltransferaza, TGT, (tRNK)-kjuin34:kjuin tRNK-D-riboziltransferaza, transfer ribonukleinska kiselina kjuin34 transglikozilaza) je enzim sa sistematskim imenom tRNK-guanozin34:kjuin tRNK-D-riboziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) guanin34 u tRNK + kveuin \rightleftharpoons kveuin34 u tRNK + guanin
(2) guanin34 u tRNK + 7-aminometil-7-karbaguanin \rightleftharpoons 7-aminometil-7-karbaguanin34 u tRNK + guanin

Pojedine prokariotske i eukariotske tRNK sadrže modifikovanu bazu kjuin u poziciji 34.

Reference[uredi - уреди]

  1. Howes, N.K. and Farkas, W.R. (1978). "Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA". J. Biol. Chem. 253: 9082–9087. PMID 721832. 
  2. Okada, N., Noguchi, S., Kasai, H., Shindo-Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1979). "Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction". J. Biol. Chem. 254: 3067–3073. PMID 372186. 
  3. Shindo-Okada, N., Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1980). "Transfer ribonucleic acid guanine transglycosylase isolated from rat liver". Biochemistry 19: 395–400. PMID 6986171. 
  4. Todorov, K.A. and Garcia, G.A. (2006). "Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity". Biochemistry 45: 617–625. PMID 16401090. 
  5. Boland, C., Hayes, P., Santa-Maria, I., Nishimura, S. and Kelly, V.P. (2009). "Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase". J. Biol. Chem. 284: 18218–18227. PMID 19414587. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]